Chronic Vascular Impairment in Heart, Brain, and Kidney Disorders: Molecular Mechanisms and Therapeutic Strategies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 416
Special Issue Editor
Interests: atherosclerosis; lipoprotein; inflammation; antioxidants; oxidative stress; cardiovascular diseases; neurodegenerative disorders, laboratory medicine and analytical method validation; nutrition and population health
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular, neurodegenerative, and renal disorders are increasingly recognized as sharing common vascular pathologies that compromise organ function and accelerate disease progression. Vascular impairment including endothelial dysfunction, blood–brain barrier disruption, glomerular injury, and microvascular rarefaction plays a central role in the pathogenesis of heart, brain, and kidney diseases. This Special Issue explores the molecular and cellular mechanisms underlying vascular dysfunction in conditions such as heart failure, stroke, Alzheimer's disease, chronic kidney disease, and vascular dementia. Key themes include the role of oxidative stress, inflammation, lipid signaling, and endothelial–mesenchymal transition in driving vascular pathology across these organ systems. Additionally, the issue highlights emerging therapeutic strategies aimed at preserving or restoring vascular integrity ranging from pharmacological interventions and lifestyle-based approaches to novel gene and cell therapies. By integrating insights from cardiovascular, neurovascular, and renal research, this collection aims to foster a more unified understanding of systemic vascular health and promote translational advances in the treatment of complex multi-organ disorders.
Dr. Mahdi O. Garelnabi
Guest Editor
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Keywords
- atherosclerosis
- lipoprotein
- inflammation
- antioxidants
- oxidative stress
- cardiovascular diseases
- neurodegenerative disorders
- blood–brain barrier
- stroke
- Alzheimer's disease
- kidney
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