Neuropeptides, Dopamine and Their Interactions in Neuroscience (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 4541

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Medical School, Institute of Physiology, University of Pécs, 7624 Pécs, Hungary
Interests: oxytocin; autism; valproate; amygdala; anxiety; rat; elevated plus maze
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Special Issue Information

Dear Colleagues,

Dopamine, as a neurotransmitter and neuromodulator, plays a crucial role in many functions within the central nervous system, such as motor behavior, motivation, reinforcement, learning and memory processes, influencing multiple neural pathways, and modulating synaptic plasticity. A dysfunction of mesencephalic dopaminergic systems, in addition to normal functions, can be observed in several neurological and psychiatric disorders. Moreover, dozens of neuropeptides are found in the central nervous system, such as substance P, neurotensin, oxytocin, and enkephalin. An accumulating body of evidence demonstrates their involvement in similar brain processes, such as dopamine. This raises the question of why such apparent redundancy is found in the brain. The answer may be found in the complex interaction between the neuropeptide and dopamine systems. In this Special Issue, we strive to unravel how dopamine and neuropeptides influence each other on various levels in the brain, mainly within the basal ganglia and the related areas, resulting in behavioral changes.

Dr. László Péczely
Guest Editor

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Keywords

  • dopamine
  • neuropeptides
  • psychiatric disorders
  • neurologic disorders
  • basal ganglia
  • behavior
  • learning and memory

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Published Papers (2 papers)

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17 pages, 9561 KiB  
Article
Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption
by Christina A. Nelson, James N. Brundage, Benjamin M. Williams, Jared K. Baldridge, Alyssa L. Stockard, Charlton H. Bassett, Brandon J. Burger, Bridger T. Gunter, Andrew J. Payne, Jordan T. Yorgason, Scott C. Steffensen and Kyle B. Bills
Biomedicines 2024, 12(7), 1593; https://doi.org/10.3390/biomedicines12071593 - 17 Jul 2024
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Abstract
Exercise has increasingly been recognized as an adjunctive therapy for alcohol-use disorder (AUD), yet our understanding of its underlying neurological mechanisms remains limited. This knowledge gap impedes the development of evidence-based exercise guidelines for AUD treatment. Chronic ethanol (EtOH) exposure has been shown [...] Read more.
Exercise has increasingly been recognized as an adjunctive therapy for alcohol-use disorder (AUD), yet our understanding of its underlying neurological mechanisms remains limited. This knowledge gap impedes the development of evidence-based exercise guidelines for AUD treatment. Chronic ethanol (EtOH) exposure has been shown to upregulate and sensitize kappa opioid receptors (KORs) in the nucleus accumbens (NAc), which is innervated by dopamine (DA) neurons in the midbrain ventral tegmental area (VTA), which may contribute to AUD-related behaviors. In this study, we investigated the impact of voluntary exercise in EtOH-dependent mice on EtOH consumption, KOR and delta opioid receptor (DOR) expression in the NAc and VTA, and functional effects on EtOH-induced alterations in DA release in the NAc. Our findings reveal that voluntary exercise reduces EtOH consumption, reduces KOR and enhances DOR expression in the NAc, and modifies EtOH-induced adaptations in DA release, suggesting a competitive interaction between exercise-induced and EtOH-induced alterations in KOR expression. We also found changes to DOR expression in the NAc and VTA with voluntary exercise but no significant changes to DA release. These findings elucidate the complex interplay of AUD-related neurobiological processes, highlighting the potential for exercise as a therapeutic intervention for AUD. Full article
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19 pages, 369 KiB  
Review
Interactions of Oxytocin and Dopamine—Effects on Behavior in Health and Disease
by Maria Petersson and Kerstin Uvnäs-Moberg
Biomedicines 2024, 12(11), 2440; https://doi.org/10.3390/biomedicines12112440 - 24 Oct 2024
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Abstract
The hypothalamic neuropeptide and hormone oxytocin are of fundamental importance for maternal, social, and sexual behavior. Deviations in oxytocin levels have also been associated with anxiety, autism spectrum disorders (ASD), depression, ADHD (attention deficit hyperactivity disorder), and schizophrenia. Both oxytocin and dopamine are [...] Read more.
The hypothalamic neuropeptide and hormone oxytocin are of fundamental importance for maternal, social, and sexual behavior. Deviations in oxytocin levels have also been associated with anxiety, autism spectrum disorders (ASD), depression, ADHD (attention deficit hyperactivity disorder), and schizophrenia. Both oxytocin and dopamine are often considered reward- and feel-good hormones, and dopamine is associated with the above-mentioned behaviors and, and dopamine is also associated with the above-mentioned behaviors and disorders. Although being structurally totally different, oxytocin, a peptide, and dopamine, a monoamine, they have a number of similar effects. They are synthesized both in the brain and in the periphery, and they affect each other’s release and receptors. In addition, oxytocin and dopamine are released in response to, for example, social interaction, sex, feeding, and massage. This review discusses interactions between oxytocin and dopamine with a specific focus on behavioral effects and possible roles of oxytocin and dopamine in various mental disorders and functional diversities. Full article
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