Protein-Protein Interactions Meet Drug Discovery
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 196
Special Issue Editors
Interests: cancer biology; chaperones; proteostasis; tumor microenvironment; protein-protein interactions
Interests: cancer biology; chaperones; protein-protein interactions; epigenetics; g-quadruplex biology; calcium signaling; chemical biology
Special Issue Information
Dear Colleagues,
Proteins regulate several critical cellular processes, such as gene expression, genome stability, and proteostasis. Most of these functions are executed with the assistance of other proteins in precise configurations. Under disease conditions, the interactions among proteins are modulated and can adopt altered networks with pathobiological significance and help the disease advance. In recent years, we have seen significant advancements in experimental methodologies and computational techniques, identifying several protein–protein interactions (PPIs) enriched or present exclusively in disease conditions. Through this issue, we aim to highlight these existing and ongoing efforts around disease-associated protein networks. We also extend a warm invitation to researchers to contribute original research or review articles that cover recent advancements in the design and synthesis of PPI modulators, including small chemical probes, natural product derivatives, and peptides affecting PPIs, their associated molecular mechanisms, and their role in different diseases.
Dr. Suhasini Joshi
Dr. Tanaya Roychowdhury
Dr. Chander S. Digwal
Guest Editors
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Keywords
- molecular chaperones
- protein-protein interactions (PPI)
- PPI modulators
- cancer
- neurodegenerative disorders
- metabolic disorders
- small molecule inhibitors
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