Advances in Targeted Therapy of Neuroblastoma
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 775
Special Issue Editor
2. Research Center for Cancer Biology, China Medical University, Taichung 110122, Taiwan
3. Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung 110122, Taiwan
Interests: cancer targeted therapy; cancer immunotherapy; post-translational modifications; chromatin remodeling
Special Issue Information
Dear Colleagues,
Neuroblastoma is the most common extracranial solid tumor of childhood. Over the past few decades, the advances in targeted therapy of neuroblastoma have greatly improved patient survival outcomes, such as ALK inhibitors, RAS-MAPK inhibitors, targeting MYCN through AURORA and BET inhibitors, epigenetic therapies, and GD2-based immunotherapy. However, many patients still develop relapsed and refractory disease. Recent progress in the developmental origin and phenotypic plasticity of neuroblastoma has provided new insights into the pathogenesis of neuroblastoma. This knowledge, along with the cutting-edge single-cell applications of next-generation sequencing technologies, will inform a further delineation of the molecular basis of neuroblastoma, as well as the development of novel biomarkers and therapies for precision medicine strategies.
Dr. Xing-Guo Li
Guest Editor
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Keywords
- neuroblastoma
- targeted therapy
- single-cell NGS technologies
- epigenetic therapy
- immunotherapy
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