Molecular and Cellular Research on Lung Cancer: A Development toward Precision Medicine

Dear Colleagues,

The past decade has been transformative for lung cancer patients, physicians and scientists.

The discovery of NSCLC mutations that confers specific sensitivity to several drugs in lung cancer adenocarcinoma and the introduction of a turning point in lung cancer immunotherapy (Anti–PD-(L)1) allowed to improve the prognosis of lung cancer and to open a new frontier of a medicine adapted to each patient: precision medicine.

The fruits of precision medicine are visible every day now in lung cancer clinical practice: patients receive molecular testing to determine whether their tumor harbors an actionable mutation and drugs targeting the immune system are showing their activity in care.

However, the extraordinary promise of precision medicine is tempered by the fact that the newest treatments are effective only in a small fraction of patients and we still known little about the tumor immune microenvironment.

This special issue will focus on cellular aspects in the development of in vitro testing devices, the discovery of new biomarkers to overcome resistance to existing treatments as well as the arrival of artificial intelligence and its implications in liquid biopsies or the stratification of organized lung cancer screening.

This special issue will be organized in 3 parts:

• Lung cancer screening and perspectives: association with AI and cancer predictive biomarkers;
• Response to treatment specific biomarkers;
• Screening strategies and innovative treatment for lung cancer: organoid-based predictive platform and novel immunotherapy pathways.

Dr. Joseph Seitlinger
Dr. Guillaume Eberst
Dr. Giuseppe Mangiameli
Guest Editors

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