Pancreatitis: Aetiology, Pathology, and Treatment
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 128
Special Issue Editor
Interests: basic, clinical, and translational research on acute pancreatitis
Special Issue Information
Dear Colleagues,
Acute pancreatitis (AP) and chronic pancreatitis (CP) are interrelated inflammatory pancreatic disorders that impose a substantial global health burden. AP is characterised by sudden pancreatic inflammation triggered by gallstones, alcohol consumption, hypertriglyceridaemia, drugs, and genetic susceptibility. Premature activation of digestive enzymes, calcium overload, mitochondrial dysfunction, endoplasmic reticulum stress, and inflammatory cascades contribute to acinar cell injury and systemic inflammatory responses, which may progress to organ failure in severe cases. Although most episodes are self-limiting, approximately 20% of patients develop moderately severe or severe disease associated with considerable morbidity, mortality, and long-term complications including pancreatic exocrine insufficiency and post-pancreatitis diabetes. CP is a progressive fibro-inflammatory disorder characterised by irreversible structural damage, pancreatic fibrosis, and gradual loss of exocrine and endocrine function, often resulting from recurrent pancreatic injury and associated with alcohol use, smoking, metabolic abnormalities, genetic variants, and ductal obstruction. Persistent inflammation promotes pancreatic stellate cell activation and extracellular matrix deposition, leading to chronic pain, malabsorption, diabetes, impaired quality of life, and increased pancreatic cancer risk. This Special Issue will provide a comprehensive platform for multidisciplinary research addressing aetiology, molecular mechanisms, pathophysiology, clinical prediction, and therapeutic strategies in pancreatitis. We welcome original research articles, reviews, and translational studies employing emerging technologies such as multi-omics, systems biology, and artificial intelligence to identify novel biomarkers and therapeutic targets, ultimately advancing precision medicine and improving clinical outcomes in pancreatitis.
Dr. Wenhao Cai
Guest Editor
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Keywords
- acute pancreatitis
- chronic pancreatitis
- inflammation
- fibrosis
- pathophysiology
- therapeutics
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