Conferences
21 February 2023, Online
Biomedicines Webinar | Molecular Targets for Biological Therapies of Severe Asthma
The molecular targets of currently available biologic therapies include human immunoglobulins E (IgE), which play a pivotal pathogenic role in allergic asthma. The anti-IgE humanized monoclonal antibody omalizumab was the first drug to be introduced for the biological treatment of severe asthma. Other biologics target either proinflammatory cytokines (IL-5, IL-4, IL-13) or their receptors, which are crucially involved in the pathophysiology of type 2 severe asthma. Mepolizumab and reslizumab are anti-IL-5 humanized monoclonal antibodies. Benralizumab is a humanized monoclonal antibody which selectively blocks the alpha subunit of the IL-5 receptor. Dupilumab is a fully human monoclonal antibody which specifically binds to the alpha subunit of the IL-4 receptor that is utilized by both IL-4 and IL-13, whose bioactivities are thus inhibited by dupilumab at the receptor level. Tezepelumab is a fully human monoclonal antibody which targets thymic stromal lymphopoietin (TSLP), an innate cytokine included within the group of alarmins (TSLP, IL-25, IL-33). TSLP is involved in direct and indirect mechanisms responsible for activation of both Th2 lymphocytes and group 2 innate lymphoid cells (ILC2).
On the basis of the above mentioned considerations, the aim of this webinar is to outline and discuss the network of cellular and molecular targets against which currently available biologics have been developed as add-on therapies for severe asthma. Therefore, I warmly welcome the outstanding speakers who kindly accepted our invitation.
The following experts will be present and talk:
- Prof. Dr. Girolamo Pelaia, Department of Health Sciences, “Magna Graecia” University of Catanzaro, Italy
- Prof. Dr. Francesco Blasi, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy, Head Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
- Dr. Enrico Heffler, Dept. Biomedical Sciences, Humanitas University, Milan, Italy
When? 21 February 2023 at 10:00 am CET | 4:00 am EST | 5:00 pm CST Asia
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You can find the Special Issue linked to this topic by clicking here.
