Matrix Metalloproteinases in Tissue Remodeling in Normal and Pathological Conditions
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2225
Special Issue Editor
Interests: cell culture in vitro; cancer cell lines; skin cells functioning; xenobiotics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Matrix metalloproteinases (MMPs) are a very important group of enzymes involved in the reconstruction of connective tissue, especially in the processes of protein degradation, including collagen. The family of metalloproteinases is divided into six groups: collagenases, gelatinases, stromelysins, matrilysins, membrane-type metalloproteinases, and other unclassified metalloproteinases. The activity of these enzymes is regulated at several levels. These include the stage of gene transcription, proteolytic activation of the zymogen, inhibition of enzymatic activity, degradation of metalloproteinases, and mRNA stability. Tissue inhibitors of metalloproteinases, TIMPs are endogenous inhibitors of metalloproteinases. Both MMP and TIMP play an important role in the organism under normal conditions and in pathological states. It is particularly important that they play an important role in all stages of cancer development: from initiation through development, metastasis to angiogenesis and apoptosis. As a result of matrix degradation, peptide growth factors are released. Metalloproteinases can also affect cell mobility by degrading E-cadherins and by regulating signals sent by integrins. The role of MMPs in supporting the development of cancer, and in particular in the formation of metastasis, is to facilitate the epithelial to mesenchymal transition and passage through the blood vessels. In the process of angiogenesis, they release angiogenic factors and degrade the ECM. On the other hand, MMPs can inhibit the growth of tumors. Therefore, both MMP and TIMP are intensively researched as potential anticancer drugs. The aim of this Special Issue is to collect information regarding matrix metalloproteinases, their structure, their activity, molecular mechanisms of their action, their influence on carcinogenesis and metastasis and their role in normal metabolism. This collection of articles will include the most relevant work in the area of matrix metalloproteinases in normal and pathological conditions with the use of the latest methodologies applied. Therefore, this Special Issue is open to comprehensive review and original research papers and addresses the following topics:
- Matrix metalloproteinases’ structure and activity
- Matrix metalloproteinases in normal and pathological conditions
- MMP role in cancer development
- TIMP role in cancer development
- MMP and TIMP as a target for new anticancer drug biosynthesis
Dr. Agata Jabłońska-Trypuć
Guest Editor
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Keywords
- matrix metalloproteinases
- cancer
- apoptosis
- angiogenesis
- metastasis
- MMP
- TIMP
- ECM
