Tailored Peptide Modifications for Advanced Infection Control Strategies, 2nd Edition
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Cellular and Molecular Bioengineering".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 67
Special Issue Editors
Interests: antimicrobial peptides; infectious diseases; vaccines; anticancer; drug resistance
Special Issues, Collections and Topics in MDPI journals
Interests: yeast-based vaccine; virus like particles; yeast-based screening; industrial application of yeast; recombinant proteins
Special Issues, Collections and Topics in MDPI journals
Interests: antimicrobial peptides; drug resistance; protein engineering; lipopeptides
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Following the success of the first edition, this second edition continues to highlight the expanding role of engineered peptides in combating infectious and immune-related diseases. Over the past few years, progress in peptide chemistry, computational modeling, and delivery platforms has accelerated the transition of antimicrobial peptides (AMPs), synthetic peptides, and peptide-based vaccines from experimental models toward clinical application. This Special Issue aims to provide a focused platform for cutting-edge research and comprehensive reviews on next-generation peptide therapeutics, from molecular design and functional modification to translational and clinical advances. Emphasis will be placed on strategies that enhance stability, selectivity, membrane targeting, and immunomodulatory performance of peptides, as well as on their combination with conventional antibiotics or immunotherapies to overcome resistance and tolerance.
Scope and Topics of Interest
Authors are invited to contribute original research papers, reviews, communications, and perspectives related, but not limited, to the following areas:
- Rational design and engineering of antimicrobial and antiviral peptides, including β-defensins, cathelicidins, and synthetic analogs.
- Structure–activity relationship (SAR) and computational modeling of peptide–membrane interactions.
- Peptide–nanomaterial conjugates and innovative delivery systems to enhance stability and tissue targeting.
- Synergistic and combination therapies integrating peptides with antibiotics, antifungals, or antivirals.
- Peptide-based vaccines and immunomodulators for infectious and inflammatory diseases.
- Peptide therapeutics in fungal and biofilm-associated infections.
- Protein and peptide engineering approaches for enhanced selectivity and reduced cytotoxicity.
- Translational and preclinical studies, including pharmacokinetic, resistance, and safety assessments.
- Emerging applications of peptides in oncology, autoimmune disorders, and host–microbiome regulation.
- Relevance and Impact
Peptide therapeutics have evolved from experimental tools to realistic candidates for clinical translation. This second edition will showcase how computational design, synthetic chemistry, and bioengineering are converging to generate peptides with improved efficacy, stability, and delivery properties. This issue will foster interdisciplinary exchange among researchers in microbiology, biophysics, structural biology, pharmacology, and biomedical engineering, supporting the development of next-generation therapeutic platforms against antimicrobial resistance and chronic infections.
Dr. Piyush Baindara
Dr. Ravinder Kumar
Dr. Santi Mohan Mandal
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- peptide-based vaccines
- drug resistance
- protein engineering
- infectious diseases
- antibacterial
- antifungal
- antiviral
- immunotherapies
- therapeutics
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