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Regenerative Medicine: From Biomaterials to Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 2148

Special Issue Editor


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Collection Editor
Institute for Health and Sport (IHES), Victoria University, Melbourne, VIC 3011, Australia
Interests: minimisation of falls risks among older adults; understanding biomechanical factors for knee osteoarthritis; effects of 3D visual perception on flooring to control walking patterns to reduce slipping risks; biomechanical modelling and simulation of the major factors of falls when older adults are walking, (i.e. tripping, slipping and balance loss); footwear ergonomics to control gait patterns
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advancement in regenerative medicine deserves strong attention due to the potential in revolutionising the conventional medical approaches. While self-immunity has been recognised as the key factor to recover various health functions at cellular levels, critically damaged or structurally altered cells have been long considered ‘incurable’ and in such cases, whereby removal or artificial interventions were the only viable options. Technology in regenerative medicine can, however, allow manipulation of gene expressions and conditioning of cellular environments via various methods. A couple of recent examples include the discovery of induced pluripotent stem (iPS) cells and the application of messenger ribonucleic acid (RNA), famous for COVID-19 vaccination. These new trends are the real hope for many severe health conditions, including spinal cord injury, cancer, cartilage regeneration, and, ultimately, ‘ageing’ itself. It is, therefore, crucial to collect and share the latest information about regeneration medicine to advance this promised field of research forward. The current collection, “Regenerative Medicine from Biomaterials to Applications”, welcomes all types of submissions that help to pioneer the research area, including original experimental research manuscripts, comprehensive reviews that summarise published findings, and also case studies that propose novel concepts and suggest important research directions.

Dr. Hanatsu Nagano
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • gene expression
  • spinal cord injury
  • cartilage regeneration

Published Papers (1 paper)

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Research

14 pages, 1594 KiB  
Article
Double-Facet Effect of Artificial Mechanical Stress on Red Blood Cell Deformability: Implications for Blood Salvage
by Tamir Tsohar, Shaul Beyth, Alexander Gural, Dan Arbell, Saul Yedgar and Gregory Barshtein
Appl. Sci. 2022, 12(19), 9951; https://doi.org/10.3390/app12199951 - 3 Oct 2022
Cited by 1 | Viewed by 1545
Abstract
The use of intra-operative blood salvage, dialysis, and artificial organs are associated with the application of non-physiological mechanical stress on red blood cells (RBCs). To explore the effect of these procedures on red cell deformability, we determined it before and after the mechanical [...] Read more.
The use of intra-operative blood salvage, dialysis, and artificial organs are associated with the application of non-physiological mechanical stress on red blood cells (RBCs). To explore the effect of these procedures on red cell deformability, we determined it before and after the mechanical stress application both in an in vitro system and following a blood-saving procedure. RBC from eight healthy donors and fifteen packed RBC units were subjected to mechanical stress. RBCs from five patients undergoing orthopedic surgery were also collected. We measured the percent of undeformable cells (%UDFC) in the red cell samples using our cell flow properties image analyzer, which provides the distribution of RBC deformability in a large cell population. Mechanical stress systematically reduced the cell deformability and increased the %UDFC, while simultaneously causing hemolysis of rigid, undeformable RBCs. Ultimately, the overall result depended on the initial level of the undeformable cells; the stress-induced change in the proportion of rigid cells (Δ%UDFC) increased (Δ%UDFC > 0) when its initial value was low, and decreased (Δ%UDFC < 0) when its initial value was high. This suggests that the final impact of mechanical stress on the percent of rigid cells in the RBC population is primarily determined by their initial concentration in the sample. Full article
(This article belongs to the Special Issue Regenerative Medicine: From Biomaterials to Applications)
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