Deep Learning and Machine Learning Applications in Biomedicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 1966

Special Issue Editor


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Guest Editor
School of Medicine and Health, Harbin Institute of Technology, Harbin 150006, China
Interests: molecular characterization of complex diseases; biological network analysis; identification of molecular regulatory relationships; molecular feature recognition

Special Issue Information

Dear Colleagues,

Biomedicine has been significantly transformed by the integration of artificial intelligence (AI) techniques, particularly machine learning (ML) and deep learning (DL). These technologies have revolutionized the way medical data are analyzed, diagnoses are made, and treatment strategies are developed. Deep learning and machine learning have been widely applied in disease diagnosis, personalized medicine, drug discovery, medical imaging, prognosis analysis, and in the explanation of pathogenic mechanisms.

As technology in the biomedical field continues to evolve, the omics categories and scale of data are experiencing continuous growth, leading to new computational method requirements. Although a large number of new methods including neural network architecture, optimization techniques, regularization methods, data enhancement strategies and transfer learning have been proposed, how to apply them to the biomedical field remains a major challenge.

This Special Issue is dedicated to the publication of cutting-edge algorithmic innovations in deep learning and machine learning, specifically applied to the biomedical field's most pressing problems.

Dr. Tianyi Zhao
Guest Editor

Manuscript Submission Information

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Keywords

  • deep learning
  • machine learning
  • disease diagnosis
  • personalized medicine
  • drug discovery
  • medical imaging
  • prognosis analysis
  • pathogenic mechanism

Published Papers (2 papers)

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Editorial

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5 pages, 168 KiB  
Editorial
Deep Learning and Machine Learning Applications in Biomedicine
by Peiyi Yan, Yaojia Liu, Yuran Jia and Tianyi Zhao
Appl. Sci. 2024, 14(1), 307; https://doi.org/10.3390/app14010307 - 29 Dec 2023
Viewed by 929
Abstract
The rise of omics research, spanning genomics, transcriptomics, proteomics, and epigenomics, has revolutionized our understanding of biological systems [...] Full article
(This article belongs to the Special Issue Deep Learning and Machine Learning Applications in Biomedicine)

Research

Jump to: Editorial

15 pages, 3414 KiB  
Article
Antimicrobial Peptide Screening from Microbial Genomes in Sludge Based on Deep Learning
by Yin-Xuan Liu, Xue-Bo Jin, Chun-Ming Xu, Hui-Jun Ma, Qi Wu, Hao-Si Liu and Zi-Meng Li
Appl. Sci. 2024, 14(5), 1936; https://doi.org/10.3390/app14051936 - 27 Feb 2024
Viewed by 611
Abstract
As the issue of traditional antibiotic resistance continues to worsen, exploring new antimicrobial substances has become crucial to addressing this challenge. Antimicrobial peptides (AMPs), recognized for their low resistance levels and minimal bacterial mutation frequencies, have garnered significant attention from researchers. However, traditional [...] Read more.
As the issue of traditional antibiotic resistance continues to worsen, exploring new antimicrobial substances has become crucial to addressing this challenge. Antimicrobial peptides (AMPs), recognized for their low resistance levels and minimal bacterial mutation frequencies, have garnered significant attention from researchers. However, traditional screening methods for AMPs are inefficient and costly. This study proposes a combined AMP screening model based on long short-term memory (LSTM) neural networks with an attention mechanism. By analyzing the characteristics of peptide segments, which are simulated enzymatic hydrolysis products of proteins expressed in sludge microbial genomes, the model accurately identifies peptide segments with potential antimicrobial activity. Molecular docking and dynamic simulation results validate three potential antimicrobial peptide candidates: LLPRLLARRY, GVREIHGLNPGGCLHTVRLVCR, and FRTTLAPHVLTRLLAPCW. These candidates exhibit high binding stability and affinity with target proteins, confirming the efficiency of the proposed AMP screening model. Full article
(This article belongs to the Special Issue Deep Learning and Machine Learning Applications in Biomedicine)
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