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Applied Sciences
Special Issues
Biomechanics of Bone Tissue and Biocompatible Materials
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Biomechanics of Bone Tissue and Biocompatible Materials

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 2115

Special Issue Editors

Prof. Dr. Alessio Gizzi

E-Mail Website
Guest Editor
Department of Engineering, Campus Bio-Medico University of Rome, Via A. del Portillo 21, 00128 Rome, Italy
Interests: bone modelling; continuum mechanics; constitutive modeling; FEM; multiphysics coupling
Special Issues, Collections and Topics in MDPI journals
Dr. Cristina Falcinelli

E-Mail Website
Guest Editor
Department of Engineering and Geology, University G. D’Annunzio Chieti-Pescara, Viale Pindaro 42, 65127 Pescara, Italy
Interests: bone biomechanics and modeling; continuum mechanics; constitutive modeling; imaging; FEM
Dr. Daniele Bianchi

E-Mail Website
Guest Editor
Department of Engineering, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy
Interests: tissue biomechanics; continuum mechanics; multiscale constitutive modeling; FEM; FEA; multiphysics coupling

Special Issue Information

Dear Colleagues,

Bone tissue is a complex material characterized by a hierarchical structure over multiple length scales. Its mechanical response depends on the properties at each length scale. Understanding the mechanical behavior at each scale and the multiscale connections between them is a fundamental requirement for developing clinical tools that can be used in the diagnosis, treatment and prevention of bone diseases and pathologies. At the same time, due to recent advances in technology such as 3D printing, the design of biomaterials for the replacement and treatment of damaged bone tissue has significantly evolved, with the aim of developing highly compatible optimal materials able to integrate within this hierarchical structure for improved treatment. In this context, computational modeling represents a powerful approach to investigating the mechanical behavior of bone (through specific-scale or multiscale models) and biomaterials, and to assessing the interaction of biomaterials with surrounding tissue structures. In addition, models can be used to develop patient-specific treatments in clinical practice, despite their clinical integration requiring an accurate validation process.

For this Special Issue, we are focused on gathering articles that reflect the state-of-the-art and the latest developments in both bone computational modeling and biomaterial design and their applications for bone tissue.

Prof. Dr. Alessio Gizzi
Dr. Cristina Falcinelli
Dr. Daniele Bianchi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomechanics
  • computational modeling
  • bone
  • multiscale modeling
  • biocompatibility
  • biomaterials
  • 3D printing

Published Papers (2 papers)

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Research

8 pages, 1444 KiB  
Communication
A New Collector Device for the Immediate Use of Particulate Autogenous Bone Grafts
by Carlos Aurelio Andreucci, Elza M. M. Fonseca and Renato N. Jorge
Appl. Sci. 2023, 13(20), 11334; https://doi.org/10.3390/app132011334 - 16 Oct 2023
Viewed by 692
Abstract
Autogenous bone grafts can be harvested from either intraoral or extraoral sources. Intra-oral sources include healing tooth extraction wounds, a bone from edentulous ridges, bone trephined from within the jaw using trephine drills, bone formed in wounds, and bone from the maxillary tuberosity, [...] Read more.
Autogenous bone grafts can be harvested from either intraoral or extraoral sources. Intra-oral sources include healing tooth extraction wounds, a bone from edentulous ridges, bone trephined from within the jaw using trephine drills, bone formed in wounds, and bone from the maxillary tuberosity, ramus, and mandibular symphysis. Extra-oral sources are the iliac crest, which provides cancellous bone marrow, and the tibia and calvaria. Autogenous bone grafting aids in probing depth reduction, gaining clinical attachment, the bone filling of osseous defects, and the regeneration of new bone, cementum, and periodontal ligaments in teeth. An innovative biomedical device is presented in the form of an autogenous bone collector that can fill defects of 96.91 mm3 with bone particulates, and may be used in bioengineered scaffolds. Experimental studies on synthetic bone have demonstrated the feasibility and applicability of the amount of bone obtained. Full article
(This article belongs to the Special Issue Biomechanics of Bone Tissue and Biocompatible Materials)
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14 pages, 2188 KiB  
Article
Enhanced µCT Imaging Protocol to Enable High-Resolution 3D Visualization of Microdamage in Rat Vertebrae
by Allison Tolgyesi, Normand Robert, Cari M. Whyne and Michael Hardisty
Appl. Sci. 2023, 13(6), 3625; https://doi.org/10.3390/app13063625 - 12 Mar 2023
Cited by 1 | Viewed by 1072
Abstract
Contrast-enhanced μCT imaging has been used to provide non-destructive 3D images of microdamage, but at a lower quality than found in histology and 2D backscatter electron (BSE) imaging. This study aimed to quantify potential improvements in microdamage characterization by enhancing µCT scanning parameters. [...] Read more.
Contrast-enhanced μCT imaging has been used to provide non-destructive 3D images of microdamage, but at a lower quality than found in histology and 2D backscatter electron (BSE) imaging. This study aimed to quantify potential improvements in microdamage characterization by enhancing µCT scanning parameters. Eleven slides from 9 rat vertebrae (healthy = 3, osteolytic metastases = 3, mixed metastases = 3) previously stained for microdamage with BaSO4 and analyzed with BSE imaging (2μm voxel spacing) were used in this study. μCT imaging conducted under varying protocols (x-ray voltage, tube current, frame averaging) demonstrated enhanced scan parameters at 90 kVp, 44 µA, 0.5 mm aluminum filter, 8 times frame averaging, and 4.9 µm voxel spacing. Post-processing with Richardson-Lucy deconvolution further deblurred the μCT images. Labeled microdamage in the baseline, enhanced and deblurred μCT images were segmented and spatially quantified vs. BSE-labeled microdamage using a probability-based correlation metric at six inflation radii. Enhanced μCT scan parameters improved damage visualization and increased spatial correlation probability with BSE images. Deblurring improved the sharpness of stain boundaries but did not significantly improve spatial correlation probabilities in comparison to the enhanced scans. This enhanced μCT protocol facilitates 3D visualization of microdamage, an indicator of bone quality important to bone damage mechanics. Full article
(This article belongs to the Special Issue Biomechanics of Bone Tissue and Biocompatible Materials)
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