IgE in Autoimmunity
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 13691
Special Issue Editor
Interests: IgE; basophils; autoimmunity; lupus nephritis; mast cells; translational research
Special Issue Information
Dear Colleagues,
Autoantibodies in autoimmune diseases are often described as major pathogenic factors. Depending on their isotype and/or their specificity, these autoantibodies can participate to either protective or deleterious pathophysiological mechanisms in various autoimmune diseases. IgE is well recognized as a pathogenic factor in IgE-mediated allergic diseases. Research from the last couple of decades could also demonstrate their key role in some autoimmune diseases. Some studies have identified total IgE and autoreactive IgE as involved in pathophysiology, as strong diagnostic and prognostic biomarkers, and/or as valuable therapeutic targets. Indeed, anti-IgE monoclonal antibody Omalizumab was tested in various autoimmune diseases and often showed promising therapeutic value. This Special Issue of Antibodies focuses on some autoimmune diseases where autoantibodies of the IgE isotype have been evidenced, with specific emphasis on different pathogenic mechanisms (specificity, immune complexes, cell types involved in their pathogenic effects, etc.), potential therapeutic targeting, and critical information that can be derived from the study of IgE autoantibodies.
Dr. Nicolas Charles
Guest Editor
Manuscript Submission Information
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Keywords
- Autoreactive IgE
- IgE-mediated pathophysiology
- Autoimmune diseases and related mechanisms
- Type 2 immunity-driven autoimmune disease exacerbation
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