Special Issue "Orthobiologics in Equine Musculoskeletal Injuries"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Equids".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editors

Dr. Laura Barrachina
E-Mail Website
Guest Editor
Laboratorio de Genética Bioquímica (LAGENBIO), Instituto Agroalimentario de Aragón IA2 - Instituto de Investigación Sanitaria de Aragón IIS, Universidad de Zaragoza, 50013, Zaragoza, Spain
Interests: equine articular cartilage repair; equine osteoarthritis model; mesenchymal stem cells; orthobiologics; immunology; translational research
Prof. Clementina Rodellar
E-Mail Website
Guest Editor
Laboratorio de Genética Bioquímica (LAGENBIO), Instituto Agroalimentario de Aragón IA2 - Instituto de Investigación Sanitaria de Aragón - IIS, Universidad de Zaragoza, 50013 Zaragoza, Spain
Interests: osteoarthritis; mesenchymal stem cells; orthobiologics; equine model; translational research; animal genetics

Special Issue Information

Dear Colleagues,

Musculoskeletal injuries are among the most common pathologic conditions in the equine species, mainly owing to the highly demanding sportive activities in which horses participate. The limited healing capacity of tendons, ligaments, or cartilage constitutes a handicap in the management of these injuries, resulting in a repaired tissue of inferior biomechanical properties. Advanced therapies involving the use of different orthobiologics, such as stem cells or acellular products, are showing encouraging results to treat these injuries, and a growing number of products are being developed and commercialized. In this rapidly evolving field, it is critical to keep up-to-date with the most recent evidence-based knowledge. This Special Issue will collect articles on the use of orthobiologics to advance the treatment of musculoskeletal injuries in horse, including literature reviews and research articles, from experimental in vitro and in vivo studies to trials and case reports. The overarching goal of this Special Issue is to serve as a useful collection of up-to-date high-quality information to contribute to the advancement of the field, owing to the relevance of the horse as a patient and as a translational large animal model.

Dr. Laura Barrachina
Prof. Clementina Rodellar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Orthobiologics
  • Stem cells
  • Acellular products
  • Tendon and ligament injuries
  • Cartilage defects
  • Osteoarthritis
  • Translational medicine

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Influence OF Inflammation, Differentiation and Compatibility for the Major Histocompatibility Complex (MHC) on the Immunomodulatory Capacity and Immunogenicity of Equine Mesenchymal Stem Cells (MSCs)
Authors: Alina Cequier1, Antonio Romero1,2, Francisco José Vázquez1,2, Sara Fuente1,2, Arantza Vitoria1,2, Pilar Zaragoza1, Clementina Rodellar1,*, Laura Barrachina1,2
Affiliation: 1 Laboratorio de Genética Bioquímica LAGENBIO - Instituto de Investigación Sanitaria de Aragón (IIS) - Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, C/Miguel Servet, 177. 50013 Zaragoza (Spain) 2 Servicio de Cirugía y Medicina Equina, Hospital Veterinario, Universidad de Zaragoza, C/Miguel Servet, 177. 50013 Zaragoza (Spain)
Abstract: Abstract Immune properties of mesenchymal stem cells (MSCs) influence their therapeutic efficacy and safety, being the horse a valuable patient and translational model to developing treatments. This study aimed at analysing the changes elicited by equine MSCs on lymphocyte subsets in vitro. Equine MSCs in basal conditions, pro-inflammatory primed or chondrogeneically differentiated were co-cultured with either autologous or allogeneic MHC-matched/mismatched lymphocytes activated with phytohemagglutinin (immune-suppressive assay) or in a modified one-way mixed leukocyte reaction (immunogenic potential). Gaining knowledge into the interaction of equine MSCs with the immune system contributes to developing safer and more effective treatments for both animals and humans.

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