Fish Diseases and Healthy Farming

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Aquatic Animals".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 304

Special Issue Editors

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China
Interests: fish diseases; virulence factors; fishery drugs; natural compounds; aquatic microbiology; antimicrobial resistance; bacterial virulence factors
Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China
Interests: aquatic parasite disease; fish epidemiology; fishery drugs; parasitic pathogens; ecological and drug control

Special Issue Information

Dear Colleagues,

Aquatic products serve as a vital source of high-quality protein for global populations. However, infectious diseases in fish and other aquatic animals lead to significant economic losses and threaten the sustainability of aquaculture. The misuse of antibiotics and other fishery drugs further exacerbates risks to food safety, environmental health, and aquatic ecosystems.

This Special Issue, "Fish Diseases and Healthy Farming," focuses on the latest research in fish pathology, disease prevention, and sustainable aquaculture practices. Topics include emerging fish diseases, pathogenesis of fish pathogens and novel approaches dealing with infectious diseases in aquaculture. By advancing knowledge in these areas, we aim to enhance fish health, improve production efficiency, and support the long-term growth of the aquaculture industry.

We look forward to receiving your contributions to the special issue.

Dr. Jing Dong
Dr. Shun Zhou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fish diseases
  • pathogenesis
  • virulence factors
  • fishery drugs
  • drug discovery
  • antibiotics
  • vaccines
  • probiotics
  • immunology
  • antimicrobial resistance
  • disease prevention
  • healthy farming
  • sustainable aquaculture
  • genomics & disease-resistant breeding

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 1429 KiB  
Article
Transcriptomic Analysis Reveals the Inhibitory Mechanism of Fisetin Against the Pathogenicity of Aeromonas hydrophila
by Jing Dong, Xinwei Ma, Shengping Li, Shun Zhou, Qiuhong Yang and Xiaohui Ai
Animals 2025, 15(16), 2415; https://doi.org/10.3390/ani15162415 - 18 Aug 2025
Viewed by 180
Abstract
Aeromonas hydrophila is an important zoonotic bacterium that is related to multiple diseases in humans, terrestrial animals, and aquatic animals. Bacterial septicemia caused by A. hydrophila often results in high mortality and severe economic losses. Antibiotics, the major approach to dealing with bacterial [...] Read more.
Aeromonas hydrophila is an important zoonotic bacterium that is related to multiple diseases in humans, terrestrial animals, and aquatic animals. Bacterial septicemia caused by A. hydrophila often results in high mortality and severe economic losses. Antibiotics, the major approach to dealing with bacterial infections, are limited due to the occurrence of antibiotic resistance. Anti-virulence strategies provide a promising approach to combat resistant bacterial infections. Here, growth curves, hemolysis, biofilm formation, and animal studies were performed to investigate the effect of fisetin against A. hydrophila. Moreover, RNA-seq technology was employed to determine the potent mechanism of fisetin. The results showed that fisetin could dose-dependently reduce the hemolytic activities mediated by aerolysin and hinder biofilm formation. Animal studies showed that treatment with 50 mg/kg fisetin could remarkably reduce the mortality to 40% in the infected group compared with fish in the fisetin-free group. Further, transcriptome analysis demonstrated that there were 565 differentially expressed genes (DEGs) after treatment with 16 μg/mL fisetin. Fisetin significantly impacted the pathways related to oxidative phosphorylation, the citrate cycle, and virulence factor regulation. Furthermore, 159 virulence-related genes were influenced after fisetin treatment. Collectively, these findings revealed that fisetin could mitigate the pathogenicity of A. hydrophila by affecting oxidative phosphorylation and the citrate cycle pathway as well as inhibiting the production of virulence factors. The study not only identified a powerful substance for managing A. hydrophila-associated diseases in aquaculture but also clarified the mechanism of plant medicines in controlling diseases caused by bacterial pathogens. Full article
(This article belongs to the Special Issue Fish Diseases and Healthy Farming)
Show Figures

Figure 1

Back to TopTop