Potential Feed With Anti-Oxidative and Anti-Inflammatory Effects in Ruminants

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 123

Special Issue Editors


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Guest Editor
Institute of Biology, Pomaranian University in Słupsk, Słupsk, Poland
Interests: plant-based feed additives; oxidative stress modulation; anti-inflammatory bioactive; animal health and productivity; phytochemicals in animal diets

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Guest Editor
Department of Internal Diseases and Diagnostics, Faculty of Veterinary Medicine and Animal Sciences, Poznan University of Life Sciences, Poznań, Poland
Interests: status health of milking cows; new methods of treatment mastitis in cows; non antibiotics methods of fighting udder pathogens; anti-inflammatory methods of combating mastitis; pharmacological methods of modulating oxidative stress
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Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the Special Issue "Potential Feed With Anti-Oxidative and Anti-Inflammatory Effects in Ruminants". The search for functional feed additives with bioactive properties has become increasingly important due to growing concerns about animal health, productivity and sustainability of livestock production. Phytogenic compounds and alternative feed sources rich in antioxidants and anti-inflammatory agents have shown promising effects on immunity, metabolic balance and overall performance in ruminants.

This Special Issue aims to explore innovative feed strategies that modulate oxidative stress and inflammatory responses in ruminants, thereby improving animal welfare and reducing reliance on antibiotics and synthetic additives. It is closely aligned with the scope of the journal, which covers advances in animal nutrition, feed science and sustainable livestock production.

In this Special Issue, original research articles and reviews are welcome.

Research areas may include (but are not limited to) the following:

  • Phytogenic feed additives with antioxidant properties;
  • Anti-inflammatory effects of alternative feed ingredients;
  • Impact of bioactive compounds on ruminant metabolism and health;
  • Sustainable feeding practices in ruminant production;
  • Nutritional strategies to improve immune function in livestock;
  • Influence of feed composition on rumen microbiota and fermentation efficiency;
  • Evaluation of agro-industrial by-products as functional feed sources;
  • Mechanisms of action of natural antioxidants in ruminant physiology;
  • Comparative studies of conventional and alternative feed additives in terms of health outcomes.
  • New strategies to improve health status using nutritional factors;
  • Pharmacological methods of modulating oxidative stress involve the use of specific drugs or compounds aimed at either reducing the production of reactive oxygen species (ROS) or enhancing the body's antioxidant defense systems to restore redox balance.

We look forward to receiving your valuable contributions.

Dr. Halyna Tkaczenko
Dr. Sebastian Smulski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytogenic feed additives
  • bioactive compounds
  • oxidative stress
  • anti-inflammatory nutrition
  • ruminant health
  • functional feed ingredients
  • immune response in livestock
  • sustainable animal nutrition
  • natural anti-oxidants
  • rumen microbiota modulation

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Published Papers (1 paper)

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Research

18 pages, 2096 KiB  
Article
Effect of Dead-Cell Limosilactobacillus ingluviei on Hematological Parameters and Jejunal Transcriptome Profile in Calves During the Weaning Period
by Chao Ban, Supreena Srisaikham, Xingzhou Tian and Pipat Lounglawan
Animals 2025, 15(13), 1905; https://doi.org/10.3390/ani15131905 (registering DOI) - 28 Jun 2025
Abstract
Weaning is challenging for dairy calves, frequently resulting in digestive issues. This highlights the importance of implementing appropriate nutritional strategies to enhance gut health and support optimal growth. Postbiotics is a promising alternative to traditional probiotics, conferring health benefits without the risks associated [...] Read more.
Weaning is challenging for dairy calves, frequently resulting in digestive issues. This highlights the importance of implementing appropriate nutritional strategies to enhance gut health and support optimal growth. Postbiotics is a promising alternative to traditional probiotics, conferring health benefits without the risks associated with live bacteria. This study aimed to investigate the effect of dietary supplementation with a postbiotic from dead-cell Limosilactobacillus ingluviei C37 (postbiotic LIC37) on blood biochemical parameters and jejunal epithelium transcriptomic profiles in calves. Fourteen Holstein bull calves were randomly allocated into two groups (n = 7). The control group (CON) received a basic diet, while the postbiotic group (DCLI) was supplemented with 1 g/d of postbiotic LIC37 for 90 days. Blood samples were collected on days 76, 83, and 90, respectively. The jejunal epithelial tissue was obtained from four randomly selected calves per group at day 90 for transcriptome analysis. The results showed that postbiotic LIC37 supplementation reduced globulin, total protein, neutrophil (Neu) levels, and neutrophil-to-lymphocyte ratio (NLR) levels in the DCLI group (p < 0.05). Transcriptomic analysis identified 76 differentially expressed genes (DEGs), with significant upregulation of genes involved in fatty acid metabolism (FABP1), intestinal barrier function (B4GALNT2), and detoxification (GSTA1), alongside downregulation of immune response regulation (FCRLA, FCRL4). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses highlighted enrichment in pathways related to glutathione metabolism, drug metabolism, and vitamin digestion, indicating that postbiotic supplementation improved detoxification, oxidative stress defense, and nutrient absorption in calves. This study provides novel insights into the molecular mechanisms underlying the benefits of postbiotic LIC37 and supports its potential as a sustainable alternative to probiotics in calf nutrition. Full article
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