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J. Pharm. BioTech Ind., Volume 2, Issue 1 (March 2025) – 3 articles

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16 pages, 5851 KiB  
Article
Multi-Level Drug Delivery System Integrated with Injectable Hydrogels and ZIF-8 for Sustained Release of Lidocaine
by Lei Jiang, Fan Fan, Xuemei Wang, Shaukat Ali, Feng Zhou and Jiantao Zhang
J. Pharm. BioTech Ind. 2025, 2(1), 3; https://doi.org/10.3390/jpbi2010003 - 14 Feb 2025
Viewed by 698
Abstract
Lidocaine plays a significant role in postoperative analgesia by effectively reducing pain. However, due to its short half-life, it is challenging for lidocaine to achieve the desired duration of analgesia in clinical settings. Drug delivery systems can regulate the release rate over time, [...] Read more.
Lidocaine plays a significant role in postoperative analgesia by effectively reducing pain. However, due to its short half-life, it is challenging for lidocaine to achieve the desired duration of analgesia in clinical settings. Drug delivery systems can regulate the release rate over time, making them one of the most effective strategies for achieving sustained release. In this work, a multi-level drug delivery system was designed using hyaluronic acid-modified zeolitic imidazolate framework-8 (HA/ZIF-8) nanoparticles and injectable hydrogels composed of modified natural polymers. Lidocaine was incorporating into the modified ZIF-8 and uniformly dispersed within the hydrogel network. The dynamic light scattering (DLS) and Fourier transform infrared spectrometer (FTIR) results indicate the successful loading of lidocaine into ZIF-8, while the X-ray diffractometer (XRD) results confirm that the loading of lidocaine did not disrupt the crystal structure of ZIF-8. The coating of hyaluronic acid on ZIF-8 enhanced cell biocompatibility, with cell viability increasing by 89% at the same concentration. This multi-level drug delivery system can be injected through a 27-guage needle. In vitro release studies demonstrated a sustained release of lidocaine for more than 4 days and kinetic simulations aligned with the Bshakar model, indicating its potential for use in long-acting analgesic preparations. Full article
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16 pages, 2180 KiB  
Article
A Precipitation-Based Process to Generate a Solid Formulation of a Therapeutic Monoclonal Antibody: An Alternative to Lyophilization
by Athanas A. Koynov, Wei Lin, Jameson R. Bothe, Luke Schenck, Bibek Parajuli, Zhao Li, Richard Ruzanski, Natalie Hoffman, Derek Frank and Zachary VanAernum
J. Pharm. BioTech Ind. 2025, 2(1), 2; https://doi.org/10.3390/jpbi2010002 - 31 Jan 2025
Viewed by 1566
Abstract
Lyophilization, or freeze-drying, is the default technique for the manufacture of solid-state formulations of therapeutic proteins. This established method offers several advantages, including improved product stability by minimizing chemical degradation, reduced storage requirements through water removal, and elimination of cold chain dependence. However, [...] Read more.
Lyophilization, or freeze-drying, is the default technique for the manufacture of solid-state formulations of therapeutic proteins. This established method offers several advantages, including improved product stability by minimizing chemical degradation, reduced storage requirements through water removal, and elimination of cold chain dependence. However, the lyophilization process itself presents limitations. It is a lengthy, batch-based operation, potentially leading to product inconsistencies and high manufacturing costs. Additionally, some proteins are susceptible to structural alterations during the freezing step, impacting their biological activity. This paper presents an alternative approach based on the co-precipitation of protein and excipients using an organic solvent. We explore the impact of various processing parameters on the viability of the formulation. We also provide an extensive characterization of proteins reconstituted from precipitated formulations and compare protein stability in solution and in lyophilized and precipitated solid formulations under long-term, accelerated, and stressed storage conditions. Full article
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3 pages, 728 KiB  
Obituary
In Memory of Ecevit Bilgili (1974–2024)
by Peter Roth, Francis Wu and Melisa Bilgili
J. Pharm. BioTech Ind. 2025, 2(1), 1; https://doi.org/10.3390/jpbi2010001 - 30 Jan 2025
Viewed by 999
Abstract
It is with immeasurable sadness that we announce the untimely passing of Prof [...] Full article
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