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Receptors, Volume 2, Issue 4

December 2023 - 5 articles

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Articles (5)

  • Article
  • Open Access
1,830 Views
20 Pages

The NR4A Orphan Receptor Modulator C-DIM12 Selectively Alters Inflammatory Mediators in Myeloid Cells

  • Sarah Aldhafiri,
  • Mariam Marai,
  • Mohamed Ismaiel,
  • Brenda Murphy,
  • Hugh E. Giffney,
  • Thomas J. Hall,
  • Evelyn P. Murphy,
  • Eoin P. Cummins and
  • Daniel Crean

18 December 2023

Orphan nuclear receptor subfamily 4A (NR4A) are key regulators of inflammatory responses, largely by their interactions with NF-κB. Over the last decade, several NR4A modulators have been developed, and they are showing potential as therapeutic...

  • Review
  • Open Access
7 Citations
5,243 Views
13 Pages

5 December 2023

Taste 2 receptors (T2Rs) are G-protein-coupled receptors responsible for sensing bitter tastes. Many studies have shown the expression of T2Rs in extraoral tissues and the unique role of T2Rs in each tissue. Single-nucleotide polymorphisms of T2Rs ar...

  • Feature Paper
  • Review
  • Open Access
3 Citations
2,372 Views
19 Pages

15 November 2023

Neuroinflammation is considered to be a significant component in a range of neuropathologies. Unfortunately, whilst its role is well recognised, the options for therapeutic intervention are limited. As such, there is a need to identify novel targets...

  • Review
  • Open Access
2,501 Views
12 Pages

11 November 2023

Binding of substance P to the tachykinin NK1 receptor is involved in numerous physiological and pathophysiological processes ranging from modulation of sensory and motor function to inflammation, cancer, and brain injury, amongst others. NK1 antagoni...

  • Review
  • Open Access
5 Citations
2,610 Views
16 Pages

9 October 2023

Atherosclerosis is a pathological condition characterized by the accumulation of plaques in the arteries, leading to cardiovascular diseases. The deposition of cholesterol in peripheral cells increases the risk of atherosclerosis. Reverse cholesterol...