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Volume 4
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10.3390/dna4010005
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Review

How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans

by
Bahaar Chawla
and
Györgyi Csankovszki
*
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1085, USA
*
Author to whom correspondence should be addressed.
DNA 2024, 4(1), 84-103; https://doi.org/10.3390/dna4010005
Submission received: 29 December 2023 / Revised: 2 February 2024 / Accepted: 5 March 2024 / Published: 11 March 2024
(This article belongs to the Special Issue DNA Organization in Model Organisms)
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Abstract

Chromatin is the complex of DNA and associated proteins found in the nuclei of living organisms. How it is organized is a major research field as it has implications for replication, repair, and gene expression. This review summarizes the current state of the chromatin organization field, with a special focus on chromatin motor complexes cohesin and condensin. Containing the highly conserved SMC proteins, these complexes are responsible for organizing chromatin during cell division. Additionally, research has demonstrated that condensin and cohesin also have important functions during interphase to shape the organization of chromatin and regulate expression of genes. Using the model organism C. elegans, the authors review the current knowledge of how these complexes perform such diverse roles and what open questions still exist in the field.
Keywords: chromatin architecture; SMC proteins; condensin; cohesin; TADs; C. elegans; dosage compensation chromatin architecture; SMC proteins; condensin; cohesin; TADs; C. elegans; dosage compensation
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MDPI and ACS Style

Chawla, B.; Csankovszki, G. How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans. DNA 2024, 4, 84-103. https://doi.org/10.3390/dna4010005

AMA Style

Chawla B, Csankovszki G. How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans. DNA. 2024; 4(1):84-103. https://doi.org/10.3390/dna4010005

Chicago/Turabian Style

Chawla, Bahaar, and Györgyi Csankovszki. 2024. "How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans" DNA 4, no. 1: 84-103. https://doi.org/10.3390/dna4010005

APA Style

Chawla, B., & Csankovszki, G. (2024). How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans. DNA, 4(1), 84-103. https://doi.org/10.3390/dna4010005

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