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DNA, Volume 3, Issue 1

March 2023 - 4 articles

Cover Story: DNA G-quadruplexes (G4s) are non-canonical secondary structures formed in guanine-rich sequences. G4s comprise polymorphic structures that are highly conserved among different species. Within the human genome, G4s are found in regulatory regions such as gene promoters and telomeres to control replication, transcription, and telomere lengthening. In the cellular context, there are several proteins named G4-binding proteins (G4BPs) that interact with G4s, either anchoring upon, stabilizing, and/or unwinding them. G4BPs play different key roles in the regulation of the endogenous G4 landscape and its associated functions. This review summarizes the current literature on G4BPs in terms of their targets and functions, providing updated insights into the regulation of G4s in living organisms. View this paper

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Review

8 Citations

17,848 Views

24 Pages

PGT-SR: A Comprehensive Overview and a Requiem for the Interchromosomal Effect

Darren K. Griffin and
Cagri Ogur

DNA2023, 3(1), 41-64;https://doi.org/10.3390/dna3010004

6 March 2023

Preimplantation genetic testing for structural rearrangements (PGT-SR) was one of the first applications of PGT, with initial cases being worked up in the Delhanty lab. It is the least well-known of the various forms of PGT but nonetheless provides e...

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Communication

4,432 Views

8 Pages

GEM-Gate: A Low-Cost, Flexible Approach to BioBrick Assembly

Chloe Bower,
Christina Harbin and
Devin Camenares

DNA2023, 3(1), 33-40;https://doi.org/10.3390/dna3010003

22 February 2023

Rapid and modular assembly of DNA parts is crucial to many synthetic biologists. This can be achieved through Golden Gate assembly, which often requires purchase and delivery of new primers for each part and assembly configuration. Here, we report on...

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Review

12 Citations

7,622 Views

20 Pages

DNA Damage and the Gut Microbiome: From Mechanisms to Disease Outcomes

Yun-Chung Hsiao,
Chih-Wei Liu,
Yifei Yang,
Jiahao Feng,
Haoduo Zhao and
Kun Lu

DNA2023, 3(1), 13-32;https://doi.org/10.3390/dna3010002

1 February 2023

Both the number of cells and the collective genome of the gut microbiota outnumber their mammalian hosts, and the metabolic and physiological interactions of the gut microbiota with the host have not yet been fully characterized. Cancer remains one o...

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Review

16 Citations

7,931 Views

12 Pages

DNA G-Quadruplex-Binding Proteins: An Updated Overview

Victoria Sanchez-Martin

DNA2023, 3(1), 1-12;https://doi.org/10.3390/dna3010001

11 January 2023

DNA G-quadruplexes (G4s) are non-canonical secondary structures formed in guanine-rich sequences. Within the human genome, G4s are found in regulatory regions such as gene promoters and telomeres to control replication, transcription, and telomere le...

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