PGT-SR: A Comprehensive Overview and a Requiem for the Interchromosomal Effect
Abstract
:1. Introduction
2. Balanced SRs in Overview
3. Robertsonian Translocations
4. Reciprocal Translocations
5. Inversions
6. Insertional Translocations and Complex Chromosomal Rearrangements
7. Practicing PGT-SR
8. Invasive Sampling Methods for PGT-SR
9. Minimally Invasive Sampling Methods for PGT-SR
10. FISH for PGT-SR
11. STR-Typing for PGT-SR
12. Comparative Genomic Hybridization (CGH) and Array Comparative Genomic Hybridization (aCGH)
13. Karyomapping and SNP Arrays for PGT-SR
14. Next-Generation Sequencing (NGS) for PGT-SR
15. Towards Universal PGT
16. Should We Deselect or De-Prioritize Carrier Embryos?
17. Developmental Characteristics of the Embryo and PGT-SR
18. Ovarian Response and Its Relevance to PGT-SR
19. Meiotic Segregation Patterns and the Number of Chromosomally Balanced Embryos Available for PGT-SR
20. The Time of Biopsy and Maternal Age: No Effect on Chromosome Segregation, but Relevant to PGT-SR Nonetheless
21. Aneuploidy and Chromosomal Mosaicism
22. Requiem for the Interchromosomal Effect (ICE)
23. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Griffin, D.K.; Ogur, C. PGT-SR: A Comprehensive Overview and a Requiem for the Interchromosomal Effect. DNA 2023, 3, 41-64. https://doi.org/10.3390/dna3010004
Griffin DK, Ogur C. PGT-SR: A Comprehensive Overview and a Requiem for the Interchromosomal Effect. DNA. 2023; 3(1):41-64. https://doi.org/10.3390/dna3010004
Chicago/Turabian StyleGriffin, Darren K., and Cagri Ogur. 2023. "PGT-SR: A Comprehensive Overview and a Requiem for the Interchromosomal Effect" DNA 3, no. 1: 41-64. https://doi.org/10.3390/dna3010004