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DNA, Volume 3, Issue 2

June 2023 - 5 articles

Cover Story: Oxime carbamates are known commercial pesticides. The easy photo homolysis of their N-O vulnerable bond creates amine and imine radicals, which seem to efficiently cause DNA photocleavage, interestingly, with high specificity, when a carbamate linker has p-Cl-Ph moiety. Irradiations such as UVB and UVA emitted by sunlight can be absorbed by most aromatic derivatives. Using artificial UVB/UVA light, DNA photocleavage has been observed at low concentrations of the compounds. The 3-NO2-Ph-carbamidoxime-related carbamoyl ester showed pesticidal activity against Bemisia tabaci, which is one of the most devastating pests of numerous crops worldwide. A qualitative test revealed a moderate specificity against the adult population, whereas it was almost zero in the absence of UVA irradiation. View this paper

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Article

1 Citations

2,835 Views

10 Pages

Identification of Proteins Specifically Assembled on a Stem-Loop Composed of a CAG Triplet Repeat

Robert P. Fuchs,
Asako Isogawa,
Joao A. Paulo and
Shingo Fujii

DNA2023, 3(2), 109-118;https://doi.org/10.3390/dna3020009

6 June 2023

Human genomic DNA contains a number of diverse repetitive sequence motifs, often identified as fragile sites leading to genetic instability. Among them, expansion events occurring at triplet repeats have been extensively studied due to their associat...

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Opinion

6 Citations

8,582 Views

5 Pages

Preimplantation Testing for Polygenic Disease (PGT-P): Brave New World or Mad Pursuit?

Darren K. Griffin and
Anthony T. Gordon

DNA2023, 3(2), 104-108;https://doi.org/10.3390/dna3020008

10 May 2023

In preimplantation testing for monogenic disease (PGT-M), we are used to specific and directed diagnoses. Preimplantation testing for polygenic disease (PGT-P), however, represents a further level of complexity in that multiple genes are tested for w...

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Editorial

1,756 Views

3 Pages

From Mutation and Repair to Therapeutics

Ashis Basu and
Deyu Li

DNA2023, 3(2), 101-103;https://doi.org/10.3390/dna3020007

27 April 2023

As DNA research has developed, in this Special Issue of DNA, we aimed to explore recent advancements, with an emphasis on the DNA damage-induced alteration of cellular functions [...]

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Article

1 Citations

2,789 Views

16 Pages

Exploration of the DNA Photocleavage Activity of O-Halo-phenyl Carbamoyl Amidoximes: Studies of the UVA-Induced Effects on a Major Crop Pest, the Whitefly Bemisia tabaci

Anastasios Panagopoulos,
Konstantina Alipranti,
Kyriaki Mylona,
Polinikis Paisidis,
Stergios Rizos,
Alexandros E. Koumbis,
Emmanouil Roditakis and
Konstantina C. Fylaktakidou

DNA2023, 3(2), 85-100;https://doi.org/10.3390/dna3020006

4 April 2023

The DNA photocleavage effect of halogenated O-carbamoyl derivatives of 4-MeO-benzamidoxime under UVB and UVA irradiation was studied in order to identify the nature, position, and number of halogens on the carbamoyl moiety that ensure photoactivity....

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Review

7 Citations

4,796 Views

20 Pages

Kinetic Studies on the 2-Oxoglutarate/Fe(II)-Dependent Nucleic Acid Modifying Enzymes from the AlkB and TET Families

Zhiyuan Peng,
Jian Ma,
Christo Z. Christov,
Tatyana Karabencheva-Christova,
Nicolai Lehnert and
Deyu Li

DNA2023, 3(2), 65-84;https://doi.org/10.3390/dna3020005

30 March 2023

Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation. In this review, we focus on the demethylation or oxidative modification that is m...

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