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Article

Incidental Carcinomas and Lesions with Uncertain Malignant Potential (B3) Discovered During Symmetrization Mammoplasty in Breast Cancer Patients—Retrospective Single-Center Experience

by
Daciana Grujic
1,2,3,
Horia Cristian
4,
Alis Dema
5,6,
Mihai Iliescu Glaja
2,7,
Teodora Hoinoiu
2,3,8,*,
Fabiana Simion
2,
Daniel Pit
2,3,7,8,
Isabela Caizer-Găitan
2,3,8 and
Cristina Oprean
6,9,10
1
Department of Plastic, Reconstructive, and Burn Surgery, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
2
Clinic of Plastic and Reconstructive Surgery, “Pius Branzeu” Emergency County Hospital, Liviu Rebreanu Blvd. No. 156, 300723 Timisoara, Romania
3
Center for Advanced Research in Cardiovascular Pathology and Hemostaseology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
4
Department of Emergency Surgery, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
5
Department of Morphopathology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania
6
ANAPATMOL Research Center, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
7
Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
8
Department of Clinical Skills, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
9
Department of Oncology, ONCOHELP Hospital, Ciprian Porumbescu Street No. 59, 300239 Timisoara, Romania
10
ONCOMED Outpatient Unit, Department of Oncology, Ciprian Porumbescu Street No. 59, 300239 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Surgeries 2026, 7(1), 10; https://doi.org/10.3390/surgeries7010010
Submission received: 25 October 2025 / Revised: 14 December 2025 / Accepted: 29 December 2025 / Published: 4 January 2026
(This article belongs to the Special Issue State-of-the-Art Research and Emerging Innovations in Plastic and Aesthetic Surgery)
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Abstract

Although occult breast carcinomas and lesions with uncertain malignant potential are rare, their incidental discovery during symmetrizing mammoplasty can significantly alter the treatment approaches and cancer staging. In the context of oncoplastic surgery, the systematic evaluation of the contralateral breast is a clinical priority that has been underexplored in Eastern Europe. Background/Objectives: This study aimed to assess the incidence and histological characteristics of incidental carcinomas and B 3 lesions detected during contralateral symmetry mammoplasty in patients with breast cancer. Methods: This retrospective study was conducted at the Plastic and Reconstructive Surgery Clinic of the “Pius Brînzeu” County Emergency Clinical Hospital in Timisoara, Romania, over six years (2018–2024), and included 180 of 256 patients who underwent contralateral breast symmetrization. Results: Among the 180 patients, 21 (11.66%) had incidental findings: eight (4.44%) had contralateral carcinomas, and 13 (7.22%) had B3 lesions. The histopathological types identified were invasive ductal carcinoma NST (one case), ductal carcinoma in situ (one case), invasive lobular carcinoma (five cases), and mucinous/papillary carcinoma (one case). Compared to the reported international range of 2–10%, our observed incidence of 11.66% reflects the unique aspects of our patient cohort and the thoroughness of our histological analyses. Conclusions: Detection of contralateral carcinomas and B3 lesions during symmetry mammoplasties underscores the importance of a multidisciplinary approach, comprehensive bilateral screening, and detailed histopathological examination of specimens.
Keywords: breast cancer; symmetrization; contralateral carcinoma; B3 lesion; oncoplastic surgery breast cancer; symmetrization; contralateral carcinoma; B3 lesion; oncoplastic surgery

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MDPI and ACS Style

Grujic, D.; Cristian, H.; Dema, A.; Glaja, M.I.; Hoinoiu, T.; Simion, F.; Pit, D.; Caizer-Găitan, I.; Oprean, C. Incidental Carcinomas and Lesions with Uncertain Malignant Potential (B3) Discovered During Symmetrization Mammoplasty in Breast Cancer Patients—Retrospective Single-Center Experience. Surgeries 2026, 7, 10. https://doi.org/10.3390/surgeries7010010

AMA Style

Grujic D, Cristian H, Dema A, Glaja MI, Hoinoiu T, Simion F, Pit D, Caizer-Găitan I, Oprean C. Incidental Carcinomas and Lesions with Uncertain Malignant Potential (B3) Discovered During Symmetrization Mammoplasty in Breast Cancer Patients—Retrospective Single-Center Experience. Surgeries. 2026; 7(1):10. https://doi.org/10.3390/surgeries7010010

Chicago/Turabian Style

Grujic, Daciana, Horia Cristian, Alis Dema, Mihai Iliescu Glaja, Teodora Hoinoiu, Fabiana Simion, Daniel Pit, Isabela Caizer-Găitan, and Cristina Oprean. 2026. "Incidental Carcinomas and Lesions with Uncertain Malignant Potential (B3) Discovered During Symmetrization Mammoplasty in Breast Cancer Patients—Retrospective Single-Center Experience" Surgeries 7, no. 1: 10. https://doi.org/10.3390/surgeries7010010

APA Style

Grujic, D., Cristian, H., Dema, A., Glaja, M. I., Hoinoiu, T., Simion, F., Pit, D., Caizer-Găitan, I., & Oprean, C. (2026). Incidental Carcinomas and Lesions with Uncertain Malignant Potential (B3) Discovered During Symmetrization Mammoplasty in Breast Cancer Patients—Retrospective Single-Center Experience. Surgeries, 7(1), 10. https://doi.org/10.3390/surgeries7010010

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