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Transplantology, Volume 3, Issue 2

June 2022 - 10 articles

Cover Story: Normothermic machine perfusion (NMP) of the liver has progressed from research to almost routine clinical use. The ability to extend preservation time, a favourable reperfusion profile, and its ability objectively assess the viability of the allograft are just some of the advantages of NMP. Furthermore, this has been shown to be a safe way to expand the donor pool by facilitating the transplantation of grafts initially declined for transplantation without compromising clinical outcomes. NMP preservation is a useful tool for the transplantation of surgically complex liver transplant candidates. The lengthening of the preservation period without further cold ischaemic injury provides logistical advantages and allows more livers to be suitable for transplantation into this often disadvantaged group. View this paper
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Articles (10)

  • Article
  • Open Access
2 Citations
2,706 Views
8 Pages

SARS-CoV-2 Infection of Unvaccinated Liver- and Kidney-Transplant Recipients: A Single-Center Experience of 103 Consecutive Cases

  • Hailey Hardgrave,
  • Allison Wells,
  • Joseph Nigh,
  • Tamara Osborn,
  • Garrett Klutts,
  • Derek Krinock,
  • Mary Katherine Rude,
  • Sushma Bhusal,
  • Lyle Burdine and
  • Emmanouil Giorgakis

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared a pandemic in March 2020. Its reported impact on solid-organ-transplant-recipient morbidity and mortality has varied. The aim of this study was to present the effect of transpl...

  • Feature Paper
  • Review
  • Open Access
17 Citations
9,353 Views
12 Pages

Dyslipidemia in Renal Transplant Recipients

  • Karolina Chmielnicka,
  • Zbigniew Heleniak and
  • Alicja Dębska-Ślizień

Dyslipidemia is a frequent complication after kidney transplantation (KT) and is an important risk factor for cardiovascular disease (CVD). Renal transplant recipients (RTRs) are considered at high, or very high, risk of CVD, which is a leading cause...

  • Editorial
  • Open Access
2,257 Views
4 Pages

COVID-19: Impact on Lung Transplant Activity at a Large Brazilian Hospital

  • Mauro Razuk Filho,
  • Lucas Matos Fernandes and
  • Paulo Manuel Pêgo-Fernandes

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in late 2019, and has caused a huge number of hospitalizations and deaths worldwide [...]

  • Review
  • Open Access
2 Citations
3,879 Views
15 Pages

Normothermic Machine Perfusion as a Tool for Safe Transplantation of High-Risk Recipients

  • Manuel Durán,
  • Angus Hann,
  • Hanns Lembach,
  • Anisa Nutu,
  • George Clarke,
  • Ishaan Patel,
  • Dimitri Sneiders,
  • Hermien Hartog,
  • Darius F. Mirza and
  • M. Thamara P. R. Perera

Normothermic machine perfusion (NMP) should no longer be considered a novel liver graft preservation strategy, but rather viewed as the standard of care for certain graft–recipient scenarios. The ability of NMP to improve the safe utilisation o...

  • Review
  • Open Access
3,025 Views
13 Pages

Updated Pathways in Cardiorenal Continuum after Kidney Transplantation

  • Agnė Laučytė-Cibulskienė,
  • Ali-Reza Biglarnia,
  • Carin Wallquist and
  • Anders Christensson

Cardiovascular disease (CVD) remains one of the leading causes for increased morbidity and mortality in chronic kidney disease (CKD). Kidney transplantation is the preferred treatment option for CKD G5. Improved perioperative and postoperative care,...

  • Case Report
  • Open Access
2,463 Views
4 Pages

One Step at a Time: A Pediatric Case of Primary Two Staged Liver Transplantation in a Child with ESLD

  • Eberhard Lurz,
  • Elisabeth Klucker,
  • Karl Reiter,
  • Robert Dalla Pozza,
  • Jens Werner,
  • Markus Guba and
  • Michael Berger

Toxic liver syndrome is a rare condition with multiorgan failure in end-stage liver disease (ESLD), and a two-stage LT following hepatectomy with a prolonged anhepatic phase is an accepted approach to bridge to transplant. This primary approach has n...

  • Article
  • Open Access
11 Citations
4,095 Views
13 Pages

Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury

  • L. Annick van Furth,
  • Henri G. D. Leuvenink,
  • Lorina Seras,
  • Inge A. M. de Graaf,
  • Peter Olinga and
  • L. Leonie van Leeuwen

Marginal donor kidneys are more likely to develop ischemia-reperfusion injury (IRI), resulting in inferior long-term outcomes. Perfusion techniques are used to attenuate IRI and improve graft quality. However, machine perfusion is still in its infanc...

  • Article
  • Open Access
2,528 Views
9 Pages

Nutritional Predictors of Cardiovascular Risk in Patients after Kidney Transplantation-Pilot Study

  • Sylwia Czaja-Stolc,
  • Paulina Wołoszyk,
  • Sylwia Małgorzewicz,
  • Andrzej Chamienia,
  • Michał Chmielewski,
  • Zbigniew Heleniak and
  • Alicja Dębska-Ślizień

Asymmetric dimethylarginine (ADMA) is a marker of endothelial damage. Research confirms the association of ADMA with an increased cardiovascular risk (CVR) among kidney transplant recipients (KTRs). Additionally, increased circulating levels of fibro...

  • Case Report
  • Open Access
3,250 Views
6 Pages

Kidney Re-Transplantation after Simultaneous Heart and Kidney Transplant: Case Study and Literature Review

  • Antonina Przybył,
  • Zbigniew Heleniak,
  • Jarosław Kobiela,
  • Iwona Stopczyńska,
  • Marian Zembala,
  • Michał Zakliczyński,
  • Leszek Domański,
  • Jacek Różański and
  • Alicja Dębska-Ślizień

The kidney is one of most frequent transplants to be performed in multi-organ transplantation. A simultaneous heart and kidney transplant (SHKT) is the best-known treatment method in patients with severe heart failure and end-stage renal disease (ESR...

  • Brief Report
  • Open Access
2 Citations
3,432 Views
9 Pages

Non-Invasive Diagnosis of Pediatric Intestinal Graft-Versus-Host Disease: A Case Series

  • Manuela Spadea,
  • Francesco Saglio,
  • Anna Opramolla,
  • Caterina Rigazio,
  • Fabio Cisarò,
  • Massimo Berger,
  • Paola Quarello,
  • Pier Luigi Calvo and
  • Franca Fagioli

Intestinal graft-versus-host disease (I-GvHD) represents a life-threatening complication in allogeneic stem cell transplantation (SCT). Unfortunately, non-invasive validated diagnostic tools to diagnose I-GvHD, evaluate treatment response, and guide...

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Transplantology - ISSN 2673-3943