Next Article in Journal
Anti-Diarrheal Effects of Wood Creosote, Seirogan, in Japanese Patients
Previous Article in Journal
Machine Learning Models for Abnormality Detection in Musculoskeletal Radiographs
Previous Article in Special Issue
The Role of Pro-Adrenomedullin as a Marker of Severe Bacterial Infection in Children: A Review
Open AccessCase Report

Rapid Decline of IFN-γ Spot-Forming Cells in Pleural Lymphocytes during Treatment in a Patient with Suspected Tuberculosis Pleurisy

1
Department of Respiratory Medicine, Kurihara Central Hospital, Miyagi 987-2205, Japan
2
Mongolian Psychosomatic Medicine Department, International Mongolian Medicine Hospital of Inner Mongolia, Huhhot 010065, China
3
Department of Health Science and Social Welfare, Kibi International University, Okayama 716-0018, Japan
4
Department of Respiratory Medicine, Sendai City Hospital, Miyagi 982-8502, Japan
*
Authors to whom correspondence should be addressed.
Reports 2019, 2(4), 27; https://doi.org/10.3390/reports2040027
Received: 22 October 2019 / Revised: 16 November 2019 / Accepted: 16 November 2019 / Published: 18 November 2019
(This article belongs to the Special Issue Case Reports in Infectious Diseases)
A differential diagnosis of tuberculosis pleurisy is often difficult. A 48-year-old Japanese man with no previous medical history visited the outpatient department for dyspnea and fever. His chest-XP and laboratory findings, especially high C-reactive protein levels, indicated pleuritis with pleural effusion. Pleural lymphocytes showed high numbers of spot forming responses in interferon gamma release assay (IGRA). Pleural effusion contained high levels of adenosine deaminase and hyaluronic acid, but no Mycobacterium tuberculosis (TB) antigen was detected by culture or polymerase chain reaction (PCR). Although the infectious agent was not detected, the clinical and laboratory findings strongly suggested that he was suffering from tuberculosis pleurisy. After treatment with anti-TB drugs, a rapid decline of spot-forming cells (SFCs) of pleural lymphocyte was observed, despite persistently high levels of other biomarkers and increased pleural lymphocytes. This case demonstrates that an IGRA of pleural lymphocytes would be useful for therapeutic diagnosis for TB pleurisy suspected for TB. View Full-Text
Keywords: tuberculosis pleurisy; interferon-gamma release assay; pleural lymphocytes tuberculosis pleurisy; interferon-gamma release assay; pleural lymphocytes
Show Figures

Figure 1

MDPI and ACS Style

Usami, O.; Chagan Yasutan, H.; Hattori, T.; Ashino, Y. Rapid Decline of IFN-γ Spot-Forming Cells in Pleural Lymphocytes during Treatment in a Patient with Suspected Tuberculosis Pleurisy. Reports 2019, 2, 27.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop