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Open AccessCase Report

Anti-Diarrheal Effects of Wood Creosote, Seirogan, in Japanese Patients

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United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan
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Taiko Pharmaceutical Co., Ltd., Uchihonmachi 3-34-14, Suita, Osaka 564-0032, Japan
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R&D Center, Taiko Pharmaceutical Co., Ltd., 1-2-1 Hikaridai, Seikacho, Sorakugun, Kyoto 619-0237, Japan
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Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan
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United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan
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Taiko Pharmaceutical Co., Ltd., Nishihonmachi 1-4-1, Nishiku, Osaka 564-0032, Japan
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Author to whom correspondence should be addressed.
Reports 2019, 2(4), 28; https://doi.org/10.3390/reports2040028
Received: 7 September 2019 / Revised: 23 September 2019 / Accepted: 9 December 2019 / Published: 10 December 2019
Wood creosote, Seirogan, is a non-prescription drug used to treat diarrhea. However, reports of its clinical use are rare. Here, we report the efficacy of wood creosote (3 capsules daily) in alleviating diarrheal symptoms in 148 patients from 10 clinics in Osaka, Japan. Wood creosote was classified to be remarkably effective, effective, partially effective, or not effective on the basis of the degree of alleviation of diarrheal symptoms. The anti-diarrheal efficacy of wood creosote soft capsules did not differ between males and females. Younger patients (21–30 years) showed greater improvement in diarrhea symptoms than elderly patients (>61 years) did. Wood creosote soft capsules were remarkably effective (44 patients), effective (71 patients), and partially effective (13 patients) in alleviating diarrhea symptoms due to a variety of causes. To the best of our knowledge, this is the first report on the clinical effectiveness of wood creosote soft capsules in treating diarrhea. View Full-Text
Keywords: diarrhea; wood creosote; Seirogan; retrospective study; soft capsule diarrhea; wood creosote; Seirogan; retrospective study; soft capsule
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MDPI and ACS Style

Takagi, M.; Ito, M.; Morino, H.; Miura, T.; Oshida, K.; Suzuki, M.; Takemori, H.; Shibata, T. Anti-Diarrheal Effects of Wood Creosote, Seirogan, in Japanese Patients. Reports 2019, 2, 28.

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