Table of Contents
High-Throughput, Volume 7, Issue 4 (December 2018)
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Cover Story (view full-size image) Mycobacterium tuberculosis, which causes tuberculosis (TB), is the leading cause of death from an [...] Read more. Mycobacterium tuberculosis, which causes tuberculosis (TB), is the leading cause of death from an infectious agent worldwide. Genome sequences for mycobacteria provide penultimate resources for identification of novel molecular targets that are useful for such applications. Phylogenomic and comparative analyses on mycobacterial genomes show that the TB-causing bacteria differ from all other mycobacteria in numerous aspects. Detailed analysis of mycobacterial protein sequences has identified 63 conserved signature inserts and deletions (CSIs) in important proteins that are exclusively found in TB-causing bacteria. Several characteristics of these CSIs highlighted here indicate that these novel genetic features provide important unexplored means for the development of novel diagnostics and also potential targets for the development of new classes of therapeutics specifically targeting the TB-complex of organisms. View this paper.