The Effect of Copolymer-Based Nanoparticle Composition (MEO2MA-OEGMA) on the Release Profile of Doxorubicin In Vitro
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Synthesis of Superparamagnetic Fe3−δO4 NPs
2.3. Synthesis of CMPETMS-Coated Fe3−δO4 MNPs (Fe3−δO4@ Silane)
2.4. Synthesis of Fe3−δO4@P(MEO2MAx−OEGMA100−x)
2.5. Drug Conjugation to MNCs
2.6. DOX Release Kinetics Analysis
3. Results
3.1. Colloidal Behavior of Nano-Objects in Physiological Environments
3.2. Release of DOX as a Function of Temperature
3.3. Release Profile and Mechanism of DOX over Time
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Samples | MEO2MA | OEGMA |
---|---|---|
Fe3−δO4@P(MEO2MA80-OEGMA20) | 1.550 mL | 0.571 mL |
Fe3−δO4@P(MEO2MA75-OEGMA25) | 1.450 mL | 0.714 mL |
Fe3−δO4@P(MEO2MA50-OEGMA50) | 1 mL | 1 mL |
Fe3−δO4@P(MEO2MA40-OEGMA60) | 1.140 mL | 1.160 mL |
Samples | LCST in Water (°C) | LCST in PBS (°C) |
---|---|---|
Fe3−δO4@P(MEO2MA80-OEGMA20) | 32 | 30 |
Fe3−δO4@P(MEO2MA75-OEGMA25) | 38 | 36 |
Fe3−δO4@P(MEO2MA50-OEGMA50) | 45 | 43 |
Fe3−δO4@P(MEO2MA40-OEGMA60) | 48 | 44 |
Zero Order | First Order | Higushi | Korsmeyer-Peppas | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Samples | T (°C) | K0 | R2 | K1 | R2 | Kh | R2 | Kkp | R2 | n |
Fe3−δO4@P(MEO2MA40-OEGMA60) | 37 | 1.215 | 0.935 | 0.686 | 0.979 | 1.101 | 0.820 | 0.491 | 0.831 | 0.375 |
Fe3−δO4@P(MEO2MA50-OEGMA50) | 37 | 1.123 | 0.958 | 0.319 | 0.983 | 1.009 | 0.892 | 0.849 | 0.826 | 0.266 |
Fe3−δO4@P(MEO2MA40-OEGMA60) | 45 | 1.310 | 0.998 | 0.309 | 0.870 | 1.122 | 0.783 | 0.792 | 0.809 | 0.230 |
Fe3−δO4@P(MEO2MA50-OEGMA50) | 45 | 1.274 | 0.996 | 0.224 | 0.890 | 1.072 | 0.799 | 0.656 | 0.841 | 0.288 |
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Ferjaoui, Z.; Gaffet, E.; Alem, H. The Effect of Copolymer-Based Nanoparticle Composition (MEO2MA-OEGMA) on the Release Profile of Doxorubicin In Vitro. Colloids Interfaces 2024, 8, 1. https://doi.org/10.3390/colloids8010001
Ferjaoui Z, Gaffet E, Alem H. The Effect of Copolymer-Based Nanoparticle Composition (MEO2MA-OEGMA) on the Release Profile of Doxorubicin In Vitro. Colloids and Interfaces. 2024; 8(1):1. https://doi.org/10.3390/colloids8010001
Chicago/Turabian StyleFerjaoui, Zied, Eric Gaffet, and Halima Alem. 2024. "The Effect of Copolymer-Based Nanoparticle Composition (MEO2MA-OEGMA) on the Release Profile of Doxorubicin In Vitro" Colloids and Interfaces 8, no. 1: 1. https://doi.org/10.3390/colloids8010001