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Mammalian Cell Behavior on Hydrophobic Substrates: Influence of Surface Properties

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CNR-ICMATE Istituto di Chimica della Materia Condensata e di Tecnologie per l’Energia, via De Marini, 6, 16149 Genova, Italy
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Institut de Nanociència i Nanotecnologia—IN2UB, Universitat de Barcelona, Avda. Diagonal, 645, 08028 Barcelona, Spain
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Departament de Bioquímica i Fisiologia, Secció de Fisiologia—Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Avda. Joan XXIII s/n, 08028 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Colloids Interfaces 2019, 3(2), 48; https://doi.org/10.3390/colloids3020048
Received: 26 March 2019 / Revised: 25 April 2019 / Accepted: 7 May 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Wetting on Micro/Nano-Scale: From Fundamentals to Application)
The influence of different surface properties holding to a modification of the substrate towards hydrophobic or superhydrophobic behavior was reviewed in this paper. Cell adhesion, their communication, and proliferation can be strongly manipulated, acting on interfacial relationship involving stiffness, surface charge, surface chemistry, roughness, or wettability. All these features can play mutual roles in determining the final properties of biomedical applications ranging from fabrics to cell biology devices. The focus of this work is the mammalian cell viability in contact with moderate to highly water repellent coatings or materials and also in combination with hydrophilic areas for more specific application. Few case studies illustrate a range of examples in which these surface properties and design can be fruitfully matched to the specific aim. View Full-Text
Keywords: biological applications; cell adhesion; hydrophobicity; superhydrophobicity; mammalian cells; protein adsorption; surfaces properties; wettability biological applications; cell adhesion; hydrophobicity; superhydrophobicity; mammalian cells; protein adsorption; surfaces properties; wettability
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MDPI and ACS Style

Ferrari, M.; Cirisano, F.; Morán, M.C. Mammalian Cell Behavior on Hydrophobic Substrates: Influence of Surface Properties. Colloids Interfaces 2019, 3, 48.

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