Design of a Thorium Metal Target for 225Ac Production at TRIUMF
AbstractWith recent impressive clinical results of targeted alpha therapy using 225Ac, significant effort has been directed towards providing a reliable and sufficient supply of 225Ac to enable widespread using of 225Ac-radiopharmaceuticals. TRIUMF has begun production of 225Ac via spallation of thorium metal with 480 MeV protons. As part of this program, a new 225Ac-production target system capable of withstanding the power deposited by the proton beam was designed and its performance simulated over a range of potential operating parameters. Special attention was given to heat transfer and stresses within the target components. The target was successfully tested in two irradiations with a 72–73 µA proton beam for a duration of 36.5 h. The decay corrected activity at end of irradiation (average ± standard deviation) was (524 ± 21) MBq (14.2 mCi) and (86 ± 13) MBq (2.3 mCi) for 225Ac and 225Ra, respectively. These correspond to saturation yields of 72.5 MBq/µA for 225Ac and 17.6 MBq/µA for 225Ra. Longer irradiations and production scale-up are planned in the future. View Full-Text
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Robertson, A.K.; Lobbezoo, A.; Moskven, L.; Schaffer, P.; Hoehr, C. Design of a Thorium Metal Target for 225Ac Production at TRIUMF. Instruments 2019, 3, 18.
Robertson AK, Lobbezoo A, Moskven L, Schaffer P, Hoehr C. Design of a Thorium Metal Target for 225Ac Production at TRIUMF. Instruments. 2019; 3(1):18.Chicago/Turabian Style
Robertson, Andrew K.; Lobbezoo, Andrew; Moskven, Louis; Schaffer, Paul; Hoehr, Cornelia. 2019. "Design of a Thorium Metal Target for 225Ac Production at TRIUMF." Instruments 3, no. 1: 18.
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