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Recovery of Molybdenum Precursor Material in the Cyclotron-Based Technetium-99m Production Cycle

Legnaro National Laboratories, Italian National Institute for Nuclear Physics (LNL-INFN), Viale dell’Università, 35020 Legnaro, Italy
Department of Physics and Astronomy, University of Padua, 35121 Padua, Italy
Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy
Author to whom correspondence should be addressed.
Instruments 2019, 3(1), 17;
Received: 22 December 2018 / Revised: 5 February 2019 / Accepted: 5 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Instruments and Methods for Cyclotron Produced Radioisotopes)
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A closed-loop technology aiming at recycling the highly 100Mo-enriched molybdenum target material has been developed in the framework of the international research efforts on the alternative, cyclotron-based 99mTc radionuclide production. The main procedure steps include (i) 100Mo-based target manufacturing; (ii) irradiation under proton beam; (iii) dissolution of 100Mo layer containing Tc radionuclides (produced by opened nuclear reaction routes) in concentrated H2O2 solution; and (iv) Mo/Tc separation by the developed radiochemical module, from which the original 100Mo comes as the “waste” alkaline aqueous fraction. Conversion of the residual 100Mo molybdates in this fraction into molybdic acids and MoO3 has been pursued by refluxing in excess of HNO3. After evaporation of the solvent to dryness, the molybdic acids and MoO3 may be isolated from NaNO3 by exploiting their different solubility in water. When dried in vacuum at 40 °C, the combined aqueous fractions provided MoO3 as a white powder. In the last recovery step MoO3 has been reduced using a temperature-controlled reactor under hydrogen overpressure. An overall recovery yield of ~90% has been established. View Full-Text
Keywords: radioisotope production; Molybdenum-100; cyclotron; molybdenum material recovery radioisotope production; Molybdenum-100; cyclotron; molybdenum material recovery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Skliarova, H.; Buso, P.; Carturan, S.; Rossi Alvarez, C.; Cisternino, S.; Martini, P.; Boschi, A.; Esposito, J. Recovery of Molybdenum Precursor Material in the Cyclotron-Based Technetium-99m Production Cycle. Instruments 2019, 3, 17.

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