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Instruments 2018, 2(3), 17; https://doi.org/10.3390/instruments2030017

Automated Purification of Radiometals Produced by Liquid Targets

1
ICNAS—Produção, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
2
ICNAS, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
*
Author to whom correspondence should be addressed.
Received: 13 August 2018 / Revised: 3 September 2018 / Accepted: 12 September 2018 / Published: 14 September 2018
(This article belongs to the Special Issue Instruments and Methods for Cyclotron Produced Radioisotopes)
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Abstract

An automated process for the production and purification of radiometals produced by irradiating liquid targets in a medical cyclotron, using a commercially available module, has been developed. The method is suitable for the production and purification of radiometals such as 68Ga, 64Cu and 61Cu through irradiation of liquid targets and is important for producing high specific activity radioisotopes with a substantial reduction in processing time and cost when compared with the solid target approach. The “liquid target” process also eliminates the need for pre- and post-irradiation target preparation and simplifies the transfer of irradiated material from target to hotcell. A 68GaCl3 solution can be obtained in about 35 min with an average yield of 73.9 ± 6.7% in less than 10 mL of volume. 64CuCl2 solutions can be obtained with an average yield of 81.2 ± 7.8% in about 1 h of processing time. A dedicated single-use disposable kit is used on a commercial IBA Synthera® extension module. View Full-Text
Keywords: liquid targets; medical cyclotron; radiometals; gallium-68; copper-64; copper-61; purification; disposable kit; radiopharmaceuticals liquid targets; medical cyclotron; radiometals; gallium-68; copper-64; copper-61; purification; disposable kit; radiopharmaceuticals
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MDPI and ACS Style

Alves, V.H.; do Carmo, S.J.C.; Alves, F.; Abrunhosa, A.J. Automated Purification of Radiometals Produced by Liquid Targets. Instruments 2018, 2, 17.

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