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Volume 12
Issue 1
10.3390/c12010003
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Article
Peer-Review Record

Differential Cytotoxic Effects of Graphene Oxide and Its Functionalized Derivatives on Colon 26 Carcinoma Cells: Implications for Cancer Therapeutic Applications

C 2026, 12(1), 3; https://doi.org/10.3390/c12010003
by Solange Amigues 1, Natalia Krasteva 2, Kamelia Hristova-Panusheva 2, Milena Keremidarska-Markova 3, Giorgio Speranza 4 and Firas Awaja 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
C 2026, 12(1), 3; https://doi.org/10.3390/c12010003
Submission received: 9 November 2025 / Revised: 7 December 2025 / Accepted: 31 December 2025 / Published: 6 January 2026
(This article belongs to the Topic Application of Graphene-Based Materials, 2nd Edition)

Round 1

Reviewer 1 Report

-

  1. Place all suffixes throughout the manuscript, e.g., lines 132-133.
  2. Capitalize first words, e.g.: ´´Figure 2. black pristine GO sheet, red GO sheet treated in 80 sccm CH4 plasma: (a) wide spectra; 224 (b) high resolution C1s spectra; (c) high resolution O1s spectra´´, ´´Table 2. element concentrations (%) estimated on the pristine and plasma treated GO paper 271 samples.´´
  3. In ´´Table 2. element concentrations (%) estimated on the pristine and plasma treated GO paper 271 samples.´´, why estimated? Why do the values in the table not have a standard deviation?
  4. Why are the error bars in Figure 6 all the same?
  5. Why are the error bars in Figure 7 in only one direction?
  6. Were studies conducted using normal colon cells to evaluate the toxic effects of GO?

Author Response

Please see attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

The author's work matches the journal and issue or topic "Application of Graphene-Based Materials, 2nd Edition". The work is interesting and suitable; however, I suggest minor revisions. My comments are below.  

My suggestions
1. Authors must explain how they confirm uniform exposure GO paper foils during functionalization.

2. The role of defects and dopants is not clear.

3. Graphene itself contains amine and hydroxyl groups. Why select the same precursor gases for plasma treatment?
4. How XPS results are validated, what is the standard for comparisons.

5. I feel IR and NMR must know fictionalization


6. What is the thickness of carbon after plasma treatment?


7. Did the authors observe any surface degradation of GO after plasma treatment?


8. Did the authors observe any differences in cell adhesion and proliferation that might be due to alterations in GO surface topography, in addition to chemistry?

9. Discussion at the conclusion is poor 

NA

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 3 Report

I have outlined my principal allegations in the preceding sections of this opinion.

I have presented all my comments in detail in the previous sections of this review, and I fully endorse them!

Author Response

Please see the attachment. 

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

-

-

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