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Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression
Open AccessFeature PaperReview

The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization

1
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, 48940 Leioa, Spain
2
Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain
3
Department of Biochemistry and Molecular Biology, University of the Basque Country, 48940 Leioa, Spain
4
Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain
5
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2021, 7(1), 3; https://doi.org/10.3390/ncrna7010003
Received: 9 December 2020 / Revised: 28 December 2020 / Accepted: 30 December 2020 / Published: 5 January 2021
(This article belongs to the Special Issue Post-transcriptional Regulation through Long Noncoding RNAs (lncRNAs))
mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance is crucial for the correct function of a wide variety of biological processes and to maintain an appropriate cellular homeostasis. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of gene expression through different molecular mechanisms, including mRNA stabilization. In this review we provide an overview on the molecular mechanisms by which lncRNAs modulate mRNA stability and decay. We focus on how lncRNAs interact with RNA binding proteins and microRNAs to avoid mRNA degradation, and also on how lncRNAs modulate epitranscriptomic marks that directly impact on mRNA stability. View Full-Text
Keywords: long non-coding RNA; mRNA stability; RNA binding protein; microRNA; gene expression long non-coding RNA; mRNA stability; RNA binding protein; microRNA; gene expression
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MDPI and ACS Style

Sebastian-delaCruz, M.; Gonzalez-Moro, I.; Olazagoitia-Garmendia, A.; Castellanos-Rubio, A.; Santin, I. The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization. Non-Coding RNA 2021, 7, 3. https://doi.org/10.3390/ncrna7010003

AMA Style

Sebastian-delaCruz M, Gonzalez-Moro I, Olazagoitia-Garmendia A, Castellanos-Rubio A, Santin I. The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization. Non-Coding RNA. 2021; 7(1):3. https://doi.org/10.3390/ncrna7010003

Chicago/Turabian Style

Sebastian-delaCruz, Maialen; Gonzalez-Moro, Itziar; Olazagoitia-Garmendia, Ane; Castellanos-Rubio, Ainara; Santin, Izortze. 2021. "The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization" Non-Coding RNA 7, no. 1: 3. https://doi.org/10.3390/ncrna7010003

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