Circular RNAs: Potential Applications as Therapeutic Targets and Biomarkers in Breast Cancer
Department of Biochemistry, University of Otago, Dunedin 9016, New Zealand
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Non-Coding RNA 2021, 7(1), 2; https://doi.org/10.3390/ncrna7010002
Received: 11 December 2020 / Revised: 26 December 2020 / Accepted: 31 December 2020 / Published: 5 January 2021
Circular RNAs (circRNAs) are a class of non-coding RNAs that form a covalently closed loop. A number of functions and mechanisms of action for circRNAs have been reported, including as miRNA sponge, exerting transcriptional and translational regulation, interacting with proteins, and coding for peptides. CircRNA dysregulation has also been implicated in many cancers, such as breast cancer. Their relatively high stability and presence in bodily fluids makes cancer-associated circRNAs promising candidates as a new biomarker. In this review, we summarize the research undertaken on circRNAs associated with breast cancer, discuss circRNAs as biomarkers, and present circRNA-based therapeutic approaches.
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MDPI and ACS Style
Sarkar, D.; Diermeier, S.D. Circular RNAs: Potential Applications as Therapeutic Targets and Biomarkers in Breast Cancer. Non-Coding RNA 2021, 7, 2. https://doi.org/10.3390/ncrna7010002
AMA Style
Sarkar D, Diermeier SD. Circular RNAs: Potential Applications as Therapeutic Targets and Biomarkers in Breast Cancer. Non-Coding RNA. 2021; 7(1):2. https://doi.org/10.3390/ncrna7010002
Chicago/Turabian StyleSarkar, Debina; Diermeier, Sarah D. 2021. "Circular RNAs: Potential Applications as Therapeutic Targets and Biomarkers in Breast Cancer" Non-Coding RNA 7, no. 1: 2. https://doi.org/10.3390/ncrna7010002
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