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Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression

Gene Expression Regulation Laboratory, Ospedale Policlinico San Martino IRCCS, 16132 Genova, Italy
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Non-Coding RNA 2020, 6(3), 40; https://doi.org/10.3390/ncrna6030040
Received: 31 August 2020 / Revised: 10 September 2020 / Accepted: 16 September 2020 / Published: 17 September 2020
(This article belongs to the Special Issue Post-transcriptional Regulation through Long Noncoding RNAs (lncRNAs))
Although mammals possess roughly the same number of protein-coding genes as worms, it is evident that the non-coding transcriptome content has become far broader and more sophisticated during evolution. Indeed, the vital regulatory importance of both short and long non-coding RNAs (lncRNAs) has been demonstrated during the last two decades. RNA binding proteins (RBPs) represent approximately 7.5% of all proteins and regulate the fate and function of a huge number of transcripts thus contributing to ensure cellular homeostasis. Transcriptomic and proteomic studies revealed that RBP-based complexes often include lncRNAs. This review will describe examples of how lncRNA-RBP networks can virtually control all the post-transcriptional events in the cell. View Full-Text
Keywords: long non-coding RNA 1; RNA binding protein 2; post-transcriptional regulation long non-coding RNA 1; RNA binding protein 2; post-transcriptional regulation
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MDPI and ACS Style

Briata, P.; Gherzi, R. Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression. Non-Coding RNA 2020, 6, 40. https://doi.org/10.3390/ncrna6030040

AMA Style

Briata P, Gherzi R. Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression. Non-Coding RNA. 2020; 6(3):40. https://doi.org/10.3390/ncrna6030040

Chicago/Turabian Style

Briata, Paola; Gherzi, Roberto. 2020. "Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression" Non-Coding RNA 6, no. 3: 40. https://doi.org/10.3390/ncrna6030040

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