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Genome-Wide Technologies to Study RNA–Chromatin Interactions

Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan
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Non-Coding RNA 2020, 6(2), 20; https://doi.org/10.3390/ncrna6020020
Received: 3 May 2020 / Revised: 23 May 2020 / Accepted: 25 May 2020 / Published: 27 May 2020
(This article belongs to the Special Issue Non-Coding RNA and Intracellular Structures)
An increasing number of studies have revealed that long non-coding RNAs (lncRNAs) play important roles in gene regulation and nuclear organization. Although the mechanisms are still largely unknown, many lncRNAs have been shown to interact with chromatin. Thus, one approach to understanding the function of these lncRNAs is to identify their sites of genomic interaction. Hybridization capture methods using oligonucleotide probes have been used for years to study chromatin-associated RNA. Recently, several groups have developed novel methods based on proximity ligation to investigate RNA–chromatin interactions at a genome-wide scale. This review discusses these technologies and highlights their advantages and disadvantages for the consideration of potential users. View Full-Text
Keywords: long non-coding RNA; chromatin-associated RNA; RNA-chromatin interaction; gene regulation long non-coding RNA; chromatin-associated RNA; RNA-chromatin interaction; gene regulation
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Kato, M.; Carninci, P. Genome-Wide Technologies to Study RNA–Chromatin Interactions. Non-Coding RNA 2020, 6, 20.

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