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Volume 6
Issue 2
10.3390/ncrna6020015
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Article

Dynamic Expression of Long Non-Coding RNAs Throughout Parasite Sexual and Neural Maturation in Schistosoma Japonicum

by
Lucas F. Maciel
1,2,
David A. Morales-Vicente
1,3 and
Sergio Verjovski-Almeida
1,3,*
1
Laboratório de Expressão Gênica em Eucariotos, Instituto Butantan, São Paulo SP 05503-900, Brazil
2
Programa Interunidades em Bioinformática, Instituto de Matemática e Estatística, Universidade de São Paulo, São Paulo SP 05508-900, Brazil
3
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo SP 05508-900, Brazil
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2020, 6(2), 15; https://doi.org/10.3390/ncrna6020015
Received: 2 March 2020 / Revised: 19 March 2020 / Accepted: 28 March 2020 / Published: 1 April 2020
(This article belongs to the Collection Feature Papers in Non-coding RNA)
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Abstract

Schistosoma japonicum is a flatworm that causes schistosomiasis, a neglected tropical disease. S. japonicum RNA-Seq analyses has been previously reported in the literature on females and males obtained during sexual maturation from 14 to 28 days post-infection in mouse, resulting in the identification of protein-coding genes and pathways, whose expression levels were related to sexual development. However, this work did not include an analysis of long non-coding RNAs (lncRNAs). Here, we applied a pipeline to identify and annotate lncRNAs in 66 S. japonicum RNA-Seq publicly available libraries, from different life-cycle stages. We also performed co-expression analyses to find stage-specific lncRNAs possibly related to sexual maturation. We identified 12,291 S. japonicum expressed lncRNAs. Sequence similarity search and synteny conservation indicated that some 14% of S. japonicum intergenic lncRNAs have synteny conservation with S. mansoni intergenic lncRNAs. Co-expression analyses showed that lncRNAs and protein-coding genes in S. japonicum males and females have a dynamic co-expression throughout sexual maturation, showing differential expression between the sexes; the protein-coding genes were related to the nervous system development, lipid and drug metabolism, and overall parasite survival. Co-expression pattern suggests that lncRNAs possibly regulate these processes or are regulated by the same activation program as that of protein-coding genes. View Full-Text
Keywords: parasitology; lncRNAs; WGCNA; gene co-expression network; synteny; nervous system parasitology; lncRNAs; WGCNA; gene co-expression network; synteny; nervous system
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MDPI and ACS Style

Maciel, L.F.; Morales-Vicente, D.A.; Verjovski-Almeida, S. Dynamic Expression of Long Non-Coding RNAs Throughout Parasite Sexual and Neural Maturation in Schistosoma Japonicum. Non-Coding RNA 2020, 6, 15. https://doi.org/10.3390/ncrna6020015

AMA Style

Maciel LF, Morales-Vicente DA, Verjovski-Almeida S. Dynamic Expression of Long Non-Coding RNAs Throughout Parasite Sexual and Neural Maturation in Schistosoma Japonicum. Non-Coding RNA. 2020; 6(2):15. https://doi.org/10.3390/ncrna6020015

Chicago/Turabian Style

Maciel, Lucas F., David A. Morales-Vicente, and Sergio Verjovski-Almeida. 2020. "Dynamic Expression of Long Non-Coding RNAs Throughout Parasite Sexual and Neural Maturation in Schistosoma Japonicum" Non-Coding RNA 6, no. 2: 15. https://doi.org/10.3390/ncrna6020015

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