Function and Evolution of Nematode RNAi Pathways
AbstractSelfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements. Amongst these, endogenous small interfering RNA and Piwi-interacting RNA (piRNA) pathways were implicated in silencing selfish genetic elements in a variety of organisms. Nematodes have several incredibly specialized, rapidly evolving endogenous RNAi-like pathways serving such purposes. Here, we review recent research regarding the RNAi-like pathways of Caenorhabditis elegans as well as those of other nematodes, to provide an evolutionary perspective. We argue that multiple nematode RNAi-like pathways share piRNA-like properties and together form a broad nematode toolkit that allows for silencing of foreign genetic elements. View Full-Text
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Almeida, M.V.; Andrade-Navarro, M.A.; Ketting, R.F. Function and Evolution of Nematode RNAi Pathways. Non-Coding RNA 2019, 5, 8.
Almeida MV, Andrade-Navarro MA, Ketting RF. Function and Evolution of Nematode RNAi Pathways. Non-Coding RNA. 2019; 5(1):8.Chicago/Turabian Style
Almeida, Miguel V.; Andrade-Navarro, Miguel A.; Ketting, René F. 2019. "Function and Evolution of Nematode RNAi Pathways." Non-Coding RNA 5, no. 1: 8.
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