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Non-Coding RNA, Volume 3, Issue 4 (December 2017) – 2 articles

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Communication
Long Non-Coding RNA TUG1 Expression Is Associated with Different Subtypes in Human Breast Cancer
by Daniela F. Gradia, Carolina Mathias, Rodrigo Coutinho, Iglenir J. Cavalli, Enilze M. S. F. Ribeiro and Jaqueline C. De Oliveira
Non-Coding RNA 2017, 3(4), 26; https://doi.org/10.3390/ncrna3040026 - 20 Dec 2017
Cited by 17 | Viewed by 4111
Abstract
Taurine upregulated 1 gene (TUG1) is a long non-coding RNA associated with several types of cancer. Recently, differential expression of TUG1 was found in cancerous breast tissues and associated with breast cancer malignancy features. Although this is evidence of a potential [...] Read more.
Taurine upregulated 1 gene (TUG1) is a long non-coding RNA associated with several types of cancer. Recently, differential expression of TUG1 was found in cancerous breast tissues and associated with breast cancer malignancy features. Although this is evidence of a potential role in breast cancer, TUG1 expression could not be associated with different subtypes, possibly due to the small number of samples analyzed. Breast cancer is a heterogeneous disease and, based on molecular signatures, may be classified into different subtypes with prognostic implications. In the present study, we include analysis of TUG1 expression in 796 invasive breast carcinoma and 105 normal samples of RNA sequencing (RNA-seq) datasets from The Cancer Genome Atlas (TCGA) and describe that TUG1 expression is increased in HER2-enriched and basal-like subtypes compared to luminal A. Additionally, TUG1 expression is associated with survival in HER2-enriched patients. These results reinforce the importance of TUG1 in breast cancer and outline its potential impact on specific subtypes. Full article
(This article belongs to the Section Long Non-Coding RNA)
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Article
Roles of Non-Coding RNA in Sugarcane-Microbe Interaction
by Flávia Thiebaut, Cristian A. Rojas, Clícia Grativol, Edmundo P. da R. Calixto, Mariana R. Motta, Helkin G. F. Ballesteros, Barbara Peixoto, Berenice N. S. De Lima, Lucas M. Vieira, Maria Emilia Walter, Elvismary M. De Armas, Júlio O. P. Entenza, Sergio Lifschitz, Laurent Farinelli, Adriana S. Hemerly and Paulo C. G. Ferreira
Non-Coding RNA 2017, 3(4), 25; https://doi.org/10.3390/ncrna3040025 - 20 Dec 2017
Cited by 7 | Viewed by 4668
Abstract
Studies have highlighted the importance of non-coding RNA regulation in plant-microbe interaction. However, the roles of sugarcane microRNAs (miRNAs) in the regulation of disease responses have not been investigated. Firstly, we screened the sRNA transcriptome of sugarcane infected with Acidovorax avenae. Conserved [...] Read more.
Studies have highlighted the importance of non-coding RNA regulation in plant-microbe interaction. However, the roles of sugarcane microRNAs (miRNAs) in the regulation of disease responses have not been investigated. Firstly, we screened the sRNA transcriptome of sugarcane infected with Acidovorax avenae. Conserved and novel miRNAs were identified. Additionally, small interfering RNAs (siRNAs) were aligned to differentially expressed sequences from the sugarcane transcriptome. Interestingly, many siRNAs aligned to a transcript encoding a copper-transporter gene whose expression was induced in the presence of A. avenae, while the siRNAs were repressed in the presence of A. avenae. Moreover, a long intergenic non-coding RNA was identified as a potential target or decoy of miR408. To extend the bioinformatics analysis, we carried out independent inoculations and the expression patterns of six miRNAs were validated by quantitative reverse transcription-PCR (qRT-PCR). Among these miRNAs, miR408—a copper-microRNA—was downregulated. The cleavage of a putative miR408 target, a laccase, was confirmed by a modified 5′RACE (rapid amplification of cDNA ends) assay. MiR408 was also downregulated in samples infected with other pathogens, but it was upregulated in the presence of a beneficial diazotrophic bacteria. Our results suggest that regulation by miR408 is important in sugarcane sensing whether microorganisms are either pathogenic or beneficial, triggering specific miRNA-mediated regulatory mechanisms accordingly. Full article
(This article belongs to the Section Detection and Biomarkers of Non-Coding RNA)
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