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Open AccessArticle

Validations of the Microchannel Flow Model for Characterizing Vascularized Tissues

1
Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA
2
Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY 14627, USA
3
Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY 14623, USA
*
Author to whom correspondence should be addressed.
Fluids 2020, 5(4), 228; https://doi.org/10.3390/fluids5040228
Received: 29 October 2020 / Revised: 24 November 2020 / Accepted: 26 November 2020 / Published: 30 November 2020
(This article belongs to the Special Issue Recent Advances in Single and Multiphase Flows in Microchannels)
The microchannel flow model postulates that stress-strain behavior in soft tissues is influenced by the time constants of fluid-filled vessels related to Poiseuille’s law. A consequence of this framework is that changes in fluid viscosity and changes in vessel diameter (through vasoconstriction) have a measurable effect on tissue stiffness. These influences are examined through the theory of the microchannel flow model. Then, the effects of viscosity and vasoconstriction are demonstrated in gelatin phantoms and in perfused tissues, respectively. We find good agreement between theory and experiments using both a simple model made from gelatin and from living, perfused, placental tissue in vitro. View Full-Text
Keywords: microchannel flow model; elasticity; shear wave speed; stress relaxation time constant; placenta; vasoconstriction microchannel flow model; elasticity; shear wave speed; stress relaxation time constant; placenta; vasoconstriction
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MDPI and ACS Style

Poul, S.S.; Ormachea, J.; Hollenbach, S.J.; Parker, K.J. Validations of the Microchannel Flow Model for Characterizing Vascularized Tissues. Fluids 2020, 5, 228. https://doi.org/10.3390/fluids5040228

AMA Style

Poul SS, Ormachea J, Hollenbach SJ, Parker KJ. Validations of the Microchannel Flow Model for Characterizing Vascularized Tissues. Fluids. 2020; 5(4):228. https://doi.org/10.3390/fluids5040228

Chicago/Turabian Style

Poul, Sedigheh S.; Ormachea, Juvenal; Hollenbach, Stefanie J.; Parker, Kevin J. 2020. "Validations of the Microchannel Flow Model for Characterizing Vascularized Tissues" Fluids 5, no. 4: 228. https://doi.org/10.3390/fluids5040228

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