Next Article in Journal
Modeling Average Pressure and Volume Fraction of a Fluidized Bed Using Data-Driven Smart Proxy
Previous Article in Journal
The Effect of Random Wind Forcing in the Nonlinear Schrödinger Equation
Previous Article in Special Issue
Image-Guided Fluid-Structure Interaction Simulation of Transvalvular Hemodynamics: Quantifying the Effects of Varying Aortic Valve Leaflet Thickness
Article Menu

Export Article

Open AccessArticle

Injection of Deformable Capsules in a Reservoir: A Systematic Analysis

1
School of Engineering, Università della Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, Italy
2
Centro di Eccellenza in Meccanica Computazionale (CEMeC), Politecnico di Bari, Via Re David 200-70125 Bari, Italy
3
Department of Mechanical Engineering, University of Bristol, Bristol BS8 1TH, UK
*
Author to whom correspondence should be addressed.
Fluids 2019, 4(3), 122; https://doi.org/10.3390/fluids4030122
Received: 29 May 2019 / Revised: 25 June 2019 / Accepted: 27 June 2019 / Published: 3 July 2019
(This article belongs to the Special Issue Cardiovascular Flows)
  |  
PDF [4200 KB, uploaded 3 July 2019]
  |  

Abstract

Motivated by red blood cell dynamics and injectable capsules for drug delivery, in this paper, a computational study of capsule ejection from a narrow channel into a reservoir is undertaken for a combination of varying deformable capsule sizes and channel dimensions. A mass-spring membrane model is coupled to an Immersed Boundary–Lattice Boltzmann model solver. The aim of the present work is the description of the capsules’ motion, deformation and the response of the fluid due to the complex particles’ dynamics. The interactions between the capsules affect the local velocity field and are responsible for the dynamics observed. Capsule membrane deformability is also seen to affect inter-capsule interaction. We observe that the train of three particles locally homogenises the velocity field and the leading capsule travels faster than the other two trailing capsules. Variations in the size of reservoir do not seem to be relevant, while the ratio of capsule diameter to channel diameter as well as the ratio of capsule diameter to inter-capsule spacing play a major role. This flow set-up has not been covered in the literature, and consequently we focus on describing capsule motion, membrane deformation and fluid dynamics, as a preliminary investigation in this field. View Full-Text
Keywords: particle transport; deforming capsule; Lattice Boltzmann; immersed boundary particle transport; deforming capsule; Lattice Boltzmann; immersed boundary
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Coclite, A.; Gambaruto, A.M. Injection of Deformable Capsules in a Reservoir: A Systematic Analysis. Fluids 2019, 4, 122.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Fluids EISSN 2311-5521 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top