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Open AccessArticle

Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil

1
Chemical & Pharmaceutical Sciences Department, University of Trieste; Via L. Giorgieri 1, 34127 Trieste, Italy
2
Department of Engineering and Architecture, University of Trieste; Via A. Valerio 6/1, 34127 Trieste, Italy
*
Author to whom correspondence should be addressed.
Received: 24 December 2018 / Revised: 19 January 2019 / Accepted: 22 January 2019 / Published: 26 January 2019
(This article belongs to the Special Issue Gels from the Self-Assembling of Peptide-Based Compounds)
In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations. View Full-Text
Keywords: peptides; d-amino acids; chirality; hydrogels; drugs; release; self-assembly; 5-fluorouracil peptides; d-amino acids; chirality; hydrogels; drugs; release; self-assembly; 5-fluorouracil
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MDPI and ACS Style

Parisi, E.; Garcia, A.M.; Marson, D.; Posocco, P.; Marchesan, S. Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil. Gels 2019, 5, 5.

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