Next Article in Journal
Influence of Structure-Directing Additives on the Properties of Poly(methylsilsesquioxane) Aerogel-Like Materials
Next Article in Special Issue
Calcium-Dependent RTX Domains in the Development of Protein Hydrogels
Previous Article in Journal
Physical Interactions Strengthen Chemical Gelatin Methacryloyl Gels
Previous Article in Special Issue
Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle

Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil

1
Chemical & Pharmaceutical Sciences Department, University of Trieste; Via L. Giorgieri 1, 34127 Trieste, Italy
2
Department of Engineering and Architecture, University of Trieste; Via A. Valerio 6/1, 34127 Trieste, Italy
*
Author to whom correspondence should be addressed.
Received: 24 December 2018 / Revised: 19 January 2019 / Accepted: 22 January 2019 / Published: 26 January 2019
(This article belongs to the Special Issue Gels from the Self-Assembling of Peptide-Based Compounds)
  |  
PDF [3865 KB, uploaded 26 January 2019]
  |  

Abstract

In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations. View Full-Text
Keywords: peptides; d-amino acids; chirality; hydrogels; drugs; release; self-assembly; 5-fluorouracil peptides; d-amino acids; chirality; hydrogels; drugs; release; self-assembly; 5-fluorouracil
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Parisi, E.; Garcia, A.M.; Marson, D.; Posocco, P.; Marchesan, S. Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil. Gels 2019, 5, 5.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Gels EISSN 2310-2861 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top