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Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil

Chemical & Pharmaceutical Sciences Department, University of Trieste; Via L. Giorgieri 1, 34127 Trieste, Italy
Department of Engineering and Architecture, University of Trieste; Via A. Valerio 6/1, 34127 Trieste, Italy
Author to whom correspondence should be addressed.
Received: 24 December 2018 / Revised: 19 January 2019 / Accepted: 22 January 2019 / Published: 26 January 2019
(This article belongs to the Special Issue Gels from the Self-Assembling of Peptide-Based Compounds)
PDF [3865 KB, uploaded 26 January 2019]


In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations. View Full-Text
Keywords: peptides; d-amino acids; chirality; hydrogels; drugs; release; self-assembly; 5-fluorouracil peptides; d-amino acids; chirality; hydrogels; drugs; release; self-assembly; 5-fluorouracil

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Parisi, E.; Garcia, A.M.; Marson, D.; Posocco, P.; Marchesan, S. Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil. Gels 2019, 5, 5.

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