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Calcium-Dependent RTX Domains in the Development of Protein Hydrogels

Department of Chemical Engineering, Columbia University, 500 W 120th Street, New York, NY 10027, USA
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Author to whom correspondence should be addressed.
Current address: Center for Engineering in Medicine, Harvard Medical School and Massachusetts General Hospital, 51 Blossom Street, Boston, MA 02114, USA.
Received: 9 January 2019 / Revised: 20 February 2019 / Accepted: 21 February 2019 / Published: 25 February 2019
(This article belongs to the Special Issue Gels from the Self-Assembling of Peptide-Based Compounds)
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Abstract

The RTX domains found in some pathogenic proteins encode repetitive peptide sequences that reversibly bind calcium and fold into the unique the β-roll secondary structure. Several of these domains have been studied in isolation, yielding key insights into their structure/function relationships. These domains are increasingly being used in protein engineering applications, where the calcium-induced control over structure can be exploited to gain new functions. Here we review recent advances in the use of RTX domains in the creation of calcium responsive biomaterials. View Full-Text
Keywords: RTX domain; beta roll domain; environmentally responsive hydrogels; calcium-dependent folding; responsive biomaterials RTX domain; beta roll domain; environmentally responsive hydrogels; calcium-dependent folding; responsive biomaterials
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bulutoglu, B.; Banta, S. Calcium-Dependent RTX Domains in the Development of Protein Hydrogels. Gels 2019, 5, 10.

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