Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3
AbstractIn this work, we report the design and fabrication of a dual-function integrated system to monitor, in real time, the release of previously loaded 2-methyl-1,4-naphthoquinone (MeNQ), also named vitamin K3. The newly developed system consists of poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles, which were embedded into a poly-γ-glutamic acid (γ-PGA) biohydrogel during the gelling reaction between the biopolymer chains and the cross-linker, cystamine. After this, agglomerates of PEDOT nanoparticles homogeneously dispersed inside the biohydrogel were used as polymerization nuclei for the in situ anodic synthesis of poly(hydroxymethyl-3,4-ethylenedioxythiophene) in aqueous solution. After characterization of the resulting flexible electrode composites, their ability to load and release MeNQ was proven and monitored. Specifically, loaded MeNQ molecules, which organized in shells around PEDOT nanoparticles agglomerates when the drug was simply added to the initial gelling solution, were progressively released to a physiological medium. The latter process was successfully monitored using an electrode composite through differential pulse voltammetry. The fabrication of electroactive flexible biohydrogels for real-time release monitoring opens new opportunities for theranostic therapeutic approaches. View Full-Text
Share & Cite This Article
Molina, B.G.; Domínguez, E.; Armelin, E.; Alemán, C. Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3. Gels 2018, 4, 86.
Molina BG, Domínguez E, Armelin E, Alemán C. Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3. Gels. 2018; 4(4):86.Chicago/Turabian Style
Molina, Brenda G.; Domínguez, Eva; Armelin, Elaine; Alemán, Carlos. 2018. "Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3." Gels 4, no. 4: 86.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.