Next Article in Journal
Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.
Next Article in Special Issue
Global Transcriptome Profiling Identified Transcription Factors, Biological Process, and Associated Pathways for Pre-Harvest Aflatoxin Contamination in Groundnut
Previous Article in Journal
Application of Disinfectants for Environmental Control of a Lethal Amphibian Pathogen
Previous Article in Special Issue
Candida albicans/Macrophage Biointerface on Human and Porcine Decellularized Adipose Matrices
Review

Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response

1
National Centre for Radiotherapy Oncology and Nuclear Medicine, Korle Bu Teaching Hospital, Accra GA-222 7974, Ghana
2
Department of Nuclear Medicine, University of Pretoria, Steve Biko Academic Hospital, Pretoria 0001, South Africa
3
Medical Imaging Center, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Joseph M. Bliss
J. Fungi 2021, 7(6), 407; https://doi.org/10.3390/jof7060407
Received: 17 April 2021 / Revised: 10 May 2021 / Accepted: 21 May 2021 / Published: 22 May 2021
(This article belongs to the Special Issue Host Defense against Fungi)
The human response to invading fungi includes a series of events that detect, kill, or clear the fungi. If the metabolic host response is unable to eliminate the fungi, an infection ensues. Some of the host response’s metabolic events to fungi can be imaged with molecules labelled with radionuclides. Several important clinical applications have been found with radiolabelled biomolecules of inflammation. 18F-fluorodeoxyglucose is the tracer that has been most widely investigated in the host defence of fungi. This tracer has added value in the early detection of infection, in staging and visualising dissemination of infection, and in monitoring antifungal treatment. Radiolabelled antimicrobial peptides showed promising results, but large prospective studies in fungal infection are lacking. Other tracers have also been used in imaging events of the host response, such as the migration of white blood cells at sites of infection, nutritional immunity in iron metabolism, and radiolabelled monoclonal antibodies. Many tracers are still at the preclinical stage. Some tracers require further studies before translation into clinical use. The application of therapeutic radionuclides offers a very promising clinical application of these tracers in managing drug-resistant fungi. View Full-Text
Keywords: fungi; host defence; inflammation; invasive fungal infections; radionuclides; PET; SPECT fungi; host defence; inflammation; invasive fungal infections; radionuclides; PET; SPECT
Show Figures

Figure 1

MDPI and ACS Style

Ankrah, A.O.; Sathekge, M.M.; Dierckx, R.A.J.O.; Glaudemans, A.W.J.M. Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response. J. Fungi 2021, 7, 407. https://doi.org/10.3390/jof7060407

AMA Style

Ankrah AO, Sathekge MM, Dierckx RAJO, Glaudemans AWJM. Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response. Journal of Fungi. 2021; 7(6):407. https://doi.org/10.3390/jof7060407

Chicago/Turabian Style

Ankrah, Alfred O., Mike M. Sathekge, Rudi A.J.O. Dierckx, and Andor W.J.M. Glaudemans 2021. "Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response" Journal of Fungi 7, no. 6: 407. https://doi.org/10.3390/jof7060407

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop