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A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., MC: 7758, San Antonio, TX 78229, USA
Author to whom correspondence should be addressed.
J. Fungi 2020, 6(1), 13;
Received: 9 December 2019 / Revised: 7 January 2020 / Accepted: 8 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue Pathogenesis of Candidiasis)
Many pathogenic Candida species possess the ability to undergo a reversible morphological transition from yeast to filamentous cells. In Candida albicans, the most frequently isolated human fungal pathogen, multiple lines of evidence strongly suggest that this transition is associated with virulence and pathogenicity. While it has generally been assumed that non-albicans Candida species (NACS) are less pathogenic than C. albicans, in part, because they do not filament as well, definitive evidence is lacking. Interestingly, however, a recent study suggests that filamentation of NACS is associated with reduced, rather than increased, pathogenicity. These findings, in turn, challenge conventional views and suggest that there are fundamental evolutionary differences in the morphology–pathogenicity relationship in C. albicans vs. NACS. The findings also raise many new and intriguing questions and open new avenues for future research, which are discussed. View Full-Text
Keywords: Candida species; morphology; pathogenesis; yeast; filaments Candida species; morphology; pathogenesis; yeast; filaments
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Kadosh, D.; Mundodi, V. A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species. J. Fungi 2020, 6, 13.

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