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J. Fungi 2019, 5(1), 4; https://doi.org/10.3390/jof5010004

A Moldy Application of MALDI: MALDI-ToF Mass Spectrometry for Fungal Identification

1
Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, MN 55905, USA
2
Department of Medicine, Mayo Clinic, Division of Infectious Diseases, Rochester, MN 55905, USA
Received: 15 November 2018 / Revised: 7 December 2018 / Accepted: 25 December 2018 / Published: 3 January 2019
(This article belongs to the Special Issue Fungal Infections in Immunocompromised Hosts)
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Abstract

As a result of its being inexpensive, easy to perform, fast and accurate, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-ToF MS) is quickly becoming the standard means of bacterial identification from cultures in clinical microbiology laboratories. Its adoption for routine identification of yeasts and even dimorphic and filamentous fungi in cultures, while slower, is now being realized, with many of the same benefits as have been recognized on the bacterial side. In this review, the use of MALDI-ToF MS for identification of yeasts, and dimorphic and filamentous fungi grown in culture will be reviewed, with strengths and limitations addressed. View Full-Text
Keywords: MALDI-ToF MS; yeast; fungus MALDI-ToF MS; yeast; fungus
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Patel, R. A Moldy Application of MALDI: MALDI-ToF Mass Spectrometry for Fungal Identification. J. Fungi 2019, 5, 4.

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