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Immune Response of Galleria mellonella against Human Fungal Pathogens

Albert Einstein College of Medicine, Bronx 10461, NY, USA
Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
Author to whom correspondence should be addressed.
J. Fungi 2019, 5(1), 3;
Received: 12 November 2018 / Revised: 14 December 2018 / Accepted: 20 December 2018 / Published: 26 December 2018
(This article belongs to the Special Issue Alternative Models for the Study of Fungal Host-Pathogen Interactions)
In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host–pathogen interactions. In recent years, the use of Galleria mellonella larvae, an insect belonging to the Lepidoptera order, has emerged as an excellent model to study the virulence of human pathogens. It is a model that offers many advantages; for example, it is easy to handle and establish in every laboratory, the larvae have a low cost, and they tolerate a wide range of temperatures, including human temperature 37 °C. The immune response of G. mellonella is innate and is divided into a cellular component (hemocytes) and humoral component (antimicrobial peptides, lytic enzymes, and peptides and melanin) that work together against different intruders. It has been shown that the immune response of this insect has a great specificity and has the ability to distinguish between different classes of microorganisms. In this review, we delve into the different components of the innate immune response of Galleria mellonella, and how these components manifest in the infection of fungal pathogens including Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Histoplasma capsulatum. View Full-Text
Keywords: Galleria mellonella; fungal pathogens; innate immunity; cellular response; humoral response Galleria mellonella; fungal pathogens; innate immunity; cellular response; humoral response
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MDPI and ACS Style

Trevijano-Contador, N.; Zaragoza, O. Immune Response of Galleria mellonella against Human Fungal Pathogens. J. Fungi 2019, 5, 3.

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