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J. Fungi 2018, 4(4), 136; https://doi.org/10.3390/jof4040136

The Zebrafish as a Model Host for Invasive Fungal Infections

1
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53716, USA
2
Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA
3
Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA
4
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA
5
Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA
6
Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Current address: Department of Biological Sciences, Clemson University, Clemson, SC 29631, USA.
*
Authors to whom correspondence should be addressed.
Received: 7 November 2018 / Revised: 10 December 2018 / Accepted: 11 December 2018 / Published: 13 December 2018
(This article belongs to the Special Issue Alternative Models for the Study of Fungal Host-Pathogen Interactions)
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Abstract

The zebrafish has become a widely accepted model host for studies of infectious disease, including fungal infections. The species is genetically tractable, and the larvae are transparent and amenable to prolonged in vivo imaging and small molecule screening. The aim of this review is to provide a thorough introduction into the published studies of fungal infection in the zebrafish and the specific ways in which this model has benefited the field. In doing so, we hope to provide potential new zebrafish researchers with a snapshot of the current toolbox and prior results, while illustrating how the model has been used well and where the unfulfilled potential of this model can be found. View Full-Text
Keywords: zebrafish; Candida; Aspergillus; Cryptococcus; mucormycosis; Talaromyces; macrophage; neutrophil; innate immunity; host–pathogen interactions zebrafish; Candida; Aspergillus; Cryptococcus; mucormycosis; Talaromyces; macrophage; neutrophil; innate immunity; host–pathogen interactions
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Rosowski, E.E.; Knox, B.P.; Archambault, L.S.; Huttenlocher, A.; Keller, N.P.; Wheeler, R.T.; Davis, J.M. The Zebrafish as a Model Host for Invasive Fungal Infections. J. Fungi 2018, 4, 136.

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